Learning Drug Interactions

Question 1

CYP INDUCERS

Answer 1

PS CROPS (decrease drug levels)
P- Phenytoin
S- Smoking
C- Carbamazepine
R- Rifampin
O- Oxcarbazepine
P- Phenobarbital
S- St. Johns Wart

Question 2

CYP INHIBITORS

Answer 2

G-PACMAN (increase drug levels)
G- Grapefruit
P- Protease Inhibitors
A- Azoles
C- Cylclosporine
M- Macrolides
A- Amiodarone
N- Non-DHP CCB

Question 3

QTc Prolongation (5 major classes)

Answer 3

Antiarrhythmics: Amiodarone, Dronedarone, sotalol, dofedtilide

Antibiotics/Antifungals: Quinolones, Macrolides, Azole antifungals, Anti-depressants, Tricyclics, SSRIs (escitalopram, citalopram)

Antipsychotics: (-azines), haloperidol, ziprasidone

Antiemetic: 5-HT3 receptor antagonist (ondansteron, prochloroperazine)

Others: Donepezil, methadone, fingolimod

Question 4

Serotonergic Toxicity

Answer 4

n

Question 5

Kill Each And Every Strong Pathogen

Answer 5

K- Klebsiella
E- Enterococci 
A-Acinetobacter
E-E.coli
S-Staph (MRSA)
P- Psuedonomas