HIV

Question 1

What is the preferred treatment for Initial ART Therapy?

Answer 1

INSTI-based + 2 NRTIs (nuc backbones)

Question 2

INSTI end in _____?

Answer 2

-GRAVIR (BRED)

• BicteGRAVIR
• RalteGRAVIR (Isentress)
• ElviteGRAVIR
• DoluteGRAVIR (Tivicay)

Question 3

BiktArvy

Answer 3

-Bictegravir/emtricitabine/TAF

Question 4

Dolutegravir SINGLE tablet combination?

Answer 4

Triumeq (dolutegravir/abacavir/lamivudine)

Question 5

Dolutegravir (Tivicay) multi-tablet combinations? (2)

Answer 5

Dolutegravir + Truvada (TDF/emtricitabine)

Dolutegravir + Descovy (TAF/emtricitabine)

Question 6

Raltegravir (Isentress) multi-tablet combinations? (2)

Answer 6

Ralegravir + Truvada (TDF/emtricitabine)

Ralegravir + Descovy (TAF/emtricitabine)

Question 7

Elvitegravir single tablet combinations? (2)

Answer 7

Elvitegravir/cobicistat/TDF/emtricitabine (StribilD)

Elvitegravir/cobicistat/TAF/emtricitabine (GenvoyA)

Question 8

NRTI’s (“good guys”)
endings:?
class effect:?

Answer 8

• bine, dine, abacavir (HLA-B5701*), tenofovir
• boxed warning: lactic acidosis and monitor LFTs
• NOF (nephrotoxicity, osteoporosis, faconi syndrome)
• LET (HBV)- lamivudine, emtiricibine, tenofovir

Question 9

Non-NRTI’s (“bad guys”)

Answer 9

Efavirenz (Atripla)- empty stomach @ bedtime
Rilpivirine (Complera)- with food; CI PPI

Class: CYP inducers, hepatotoxicity, rash

Question 10

Protease inhibitors (“bad guys”)

Answer 10

Daranavir(IPrezista)- sulfa allergy
Atazanavir (Reyataz)- acidic environment + hyperbilirubinmia (gallstones, kidney stones)

Class: CYP inhibitors, hepatoxicity, metabolic abnormalities, rash

Question 11

INSTI’s (Renal adjustments)

Answer 11

Stribild < 70 ml/min
Triumeq < 50 ml/min
Genvoya/Bictarvy < 30 ml/min