Lead Flashcards
what are some household exposure things for lead
paint, dust, dyes, ceramine glazes
what is a major route of lead for most of the population
food and water, maybe air
what is a main thing that Pb does to blood
interferes with heme synthesis
what are 2 things that are sensitive to Pb with heme
delta-aminolevulinic acid dehydratas (ALAD) and ferrochelatase
what are 2 results with Pb inhibiting ALAD and ferrochelatase
depressed hematocrit/ RBC and anemia
what happens in severe Pb cases with anemia
RBCs end up with protophorphyrin chelated to zinc instead of hemoglobin chelated to iron
what does ferrochelatase do
catalyzes the insertion of iron into the protoporphyrin ring to form heme
what does ALAD do
joins 2 ALA units to form porphobilinogen
where does 2 ALA join via ALAD to become porphobilinogen
outside of the cell
what happens once porphobilinogen is made
it gets into the cell, mitochondria, some steps then you get protoporphyrin which should become heme
how does PB inhibit heme synthesis (where in the pathway)
blocks ALAD and ferrochelatase
what is a physical way to see if someone has lead poisoning
burtons line
what is burtons line
bluish purple line at the interface of gums and teeth
why do you get burtons line with lead
reaction with lead with sulphur ions released by oral bacteria resulting in lead sulphide deposition
what can make burtons line thicker
bad oral hygiene
