LCIS - Lobar Carcinoma in situ

Question 1

What is lobar carcinoma in situ

Answer 1

An incidental finding of cellular characteristics in under microscopy

Question 2

How is the condition diagnosed?

Answer 2

By laboratory diagnosis

Question 3

What is the main micropathological feature?

Answer 3

Distortion and expansion of lobules and acini

Question 4

What is the an acini?

Answer 4

The functional unit that make up a lobule

Question 5

What are classic genetic features of lobar cancer in situ?

Answer 5

Low grade ER (estrogen) and PR (progesterone) positive cancer

Question 6

Is LCIS negative for HER2 (Human Epidermal Growth Factor 2)

Answer 6

Yes

Question 7

What is the process of diagnosis

Answer 7

• Mammogram
• Core Needle Biopsy
• Fine needle biopsy

Question 8

Is Lobar Carcinoma in situ have a risk for invasive carcinoma?

Answer 8

Yes

Question 9

What is the management of lobar carcinoma in situ?

Answer 9

Not all LCIS develop into an invasive carcinoma. Therefore observation is the preferred approach.

Surgery may be needed later

Tamoxifen, and screening are used to reduce risk

More aggressive treatment bilateral prophylactic mastectomy