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Microm442! > Lc 13 > Flashcards

Lc 13 Flashcards

1
Q

Why are chlamydiaceae and rickettside often grouped together?

A

Because they are obligate intracellular bacteria

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2
Q

What are three pathogenic chlamydiaceae?

A

Chlamydia trachomatis - urogenital and ocular infections

Chlamydophila pneumonia - respiratory tract infections

Chlamydophila psittaci- pneumonia acquired through birds

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3
Q

Explain two forms of family chlamydiaceae and their characteristics

A

Elementary body(EB)
-infectious
-Extracellular spore like form
-stabilized by outermembrane protein disulfide crosslinking

Reticulate body (RE)
-non infectious
- intracellular repilcation(divide within membrane bound inclusion
-cannot survive outside

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4
Q

What are some molecules that family chlamydiaceae unable to produce?

A

Amino acids, lipids, ATP,GTP,UTP

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5
Q

Both EB and RB produce what kind of secretion system?

A

Type 3

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6
Q

How do EB induce epithelia cell internalization?

A

Pre formed Tarp secreted into the cell and induces (actin polymerization)phagocytosis of EB

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7
Q

What do RBs secrete?

A

Inc proteins, proteases, anti apoptotic factors

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8
Q

What immune response is chlamydia trachomatis controlled by?

A

Th1(interferon gamma associated)

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9
Q

Match each serovers with corresponding disease.

A

A,B,Ba,C -Trachoma
D—K - urethretis/cervicitis, perinatal infections, inclusion conjunctivities

L1,L2,L3 - Lymphogranuloma venereum

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10
Q

What serovars survive in phagocytes?

A

LGV serovars

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11
Q

What common symptoms does men and women both have when infected with trachomatis?

A

Dysuria

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12
Q

Is cervicitis mostly asymptomatic?

A

Yes

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13
Q

What are some types of pelvic inflammatory diseases?

A

Endometritis, salpingitis,peritonitis

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14
Q

PID symptoms are bleeding, discharge, abdominal tenderness and pain. What happens when the infection persists?

A

Chronic pelvic pain syndrome, tube infertiity

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15
Q

Who are infected by both inclusion conjunctivitis and pneumonia

A

Infants and mothers

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16
Q

Inclusion conjunctivitis and pneumonia symptoms

A

Watery discharge,eyes swell,

Rapid breathing, cough, long term respiratory problems

17
Q

What are some diagnosis for c.trachomatis?

A

Nucleic acid ampification techniques(NAAT), and screening

18
Q

What is trachoma and why is it so severe?

A

Eye infection, bc of the repeated reinfection

19
Q

Trachoma mostly occurs in what age group?
How does the transmission occur?

A

Children! Children are reservoirs,
From eye and nasopharyngeal secretions via handsflies,objects

20
Q

How can pneumoniae be transmitted?

A

Person to person droplets

21
Q

Is c.pneumoniae clinically indistinguishable with other pnemoinae?

A

Yes

22
Q

C.pneumoniae infects and multiples within wide range of cell types including macrophages . Does it contribute to transport from lungs to circulation?

A

Yes

23
Q

There is no vaccine for chlamydia. However it can be treated with antibiotics. True?

A

True

24
Q

How does transmission of rickettsiales occur?

A

By arthropods vectors(tick bites)

25
Q

What type of bacteria is rickettsiales?

A

Gram negative bacteria

26
Q

Do do rickettssi transmit infection?

A

Enter circulation through tick bites,and the enters endothelial cells and do independent metabolism . They do cell to cell interaction by exiting cell membrane

27
Q

What are some symptoms for rickettssii?

A

Fever, muscle pain, maculopapular rash

28
Q

Can ricekettsii be trated with antibiotics?

A

Yes (Doxycycline)

29
Q

What are the three typhus groups?

A

R. Prowazekii, R.typhi, R.felis

30
Q

How does R. Prowazekii spread among human?

A

Transmitted by human body lice. Infected louse feces transmit bacteria into skin

31
Q

R. Thphi and R. Felis ate endemic murine typhus. What kind of disease are they?

A

Flea borne disease

32
Q

What is ehrlichiosis and how do they infect humans?

A

They are tick borne infection

Bacteria infect leukocytes and cause human monocytic ehrlichiosis and human granulocytic anaplasmosis.

33
Q

Ehrlichiosis symptom is similar to RMSF but different in what trait?

A

No rash

34
Q

How do ehrlichiosis spread disease?

A

They are obligated to intracellular bacteria.
They replicare within inclusions and inhibit lysosomal fusion.

35
Q

What are the chronic inflammatory response of chlamydia?

A

Scarring

Microm442! (8 decks)

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