Lc 13 Flashcards
Why are chlamydiaceae and rickettside often grouped together?
Because they are obligate intracellular bacteria
What are three pathogenic chlamydiaceae?
Chlamydia trachomatis - urogenital and ocular infections
Chlamydophila pneumonia - respiratory tract infections
Chlamydophila psittaci- pneumonia acquired through birds
Explain two forms of family chlamydiaceae and their characteristics
Elementary body(EB)
-infectious
-Extracellular spore like form
-stabilized by outermembrane protein disulfide crosslinking
Reticulate body (RE)
-non infectious
- intracellular repilcation(divide within membrane bound inclusion
-cannot survive outside
What are some molecules that family chlamydiaceae unable to produce?
Amino acids, lipids, ATP,GTP,UTP
Both EB and RB produce what kind of secretion system?
Type 3
How do EB induce epithelia cell internalization?
Pre formed Tarp secreted into the cell and induces (actin polymerization)phagocytosis of EB
What do RBs secrete?
Inc proteins, proteases, anti apoptotic factors
What immune response is chlamydia trachomatis controlled by?
Th1(interferon gamma associated)
Match each serovers with corresponding disease.
A,B,Ba,C -Trachoma
D—K - urethretis/cervicitis, perinatal infections, inclusion conjunctivities
L1,L2,L3 - Lymphogranuloma venereum
What serovars survive in phagocytes?
LGV serovars
What common symptoms does men and women both have when infected with trachomatis?
Dysuria
Is cervicitis mostly asymptomatic?
Yes
What are some types of pelvic inflammatory diseases?
Endometritis, salpingitis,peritonitis
PID symptoms are bleeding, discharge, abdominal tenderness and pain. What happens when the infection persists?
Chronic pelvic pain syndrome, tube infertiity
Who are infected by both inclusion conjunctivitis and pneumonia
Infants and mothers
Inclusion conjunctivitis and pneumonia symptoms
Watery discharge,eyes swell,
Rapid breathing, cough, long term respiratory problems
What are some diagnosis for c.trachomatis?
Nucleic acid ampification techniques(NAAT), and screening
What is trachoma and why is it so severe?
Eye infection, bc of the repeated reinfection
Trachoma mostly occurs in what age group?
How does the transmission occur?
Children! Children are reservoirs,
From eye and nasopharyngeal secretions via handsflies,objects
How can pneumoniae be transmitted?
Person to person droplets
Is c.pneumoniae clinically indistinguishable with other pnemoinae?
Yes
C.pneumoniae infects and multiples within wide range of cell types including macrophages . Does it contribute to transport from lungs to circulation?
Yes
There is no vaccine for chlamydia. However it can be treated with antibiotics. True?
True
How does transmission of rickettsiales occur?
By arthropods vectors(tick bites)
What type of bacteria is rickettsiales?
Gram negative bacteria
Do do rickettssi transmit infection?
Enter circulation through tick bites,and the enters endothelial cells and do independent metabolism . They do cell to cell interaction by exiting cell membrane
What are some symptoms for rickettssii?
Fever, muscle pain, maculopapular rash
Can ricekettsii be trated with antibiotics?
Yes (Doxycycline)
What are the three typhus groups?
R. Prowazekii, R.typhi, R.felis
How does R. Prowazekii spread among human?
Transmitted by human body lice. Infected louse feces transmit bacteria into skin
R. Thphi and R. Felis ate endemic murine typhus. What kind of disease are they?
Flea borne disease
What is ehrlichiosis and how do they infect humans?
They are tick borne infection
Bacteria infect leukocytes and cause human monocytic ehrlichiosis and human granulocytic anaplasmosis.
Ehrlichiosis symptom is similar to RMSF but different in what trait?
No rash
How do ehrlichiosis spread disease?
They are obligated to intracellular bacteria.
They replicare within inclusions and inhibit lysosomal fusion.
What are the chronic inflammatory response of chlamydia?
Scarring
