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Sys Pharmaco GIT > Laxatives > Flashcards

Laxatives Flashcards

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Git Commands flashcards
1
Q

Laxatives Types?

A
  1. Bulk Laxatives
  2. Stool Surfactant
  3. Osmotic Laxatives
  4. Stimulant Laxatives
  5. Opioid Receptor Antagonists
  6. Chloride Channel Activator
  7. 5-HT4 Antagonists
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2
Q

Bulk Laxatives drugs?

A

Polycarbophil

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3
Q

Bulk Laxatives mechanism of actions?

A

• Increased fluid retention leading to increased stool mass

promoting peristalsis and evacuation

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4
Q

Bulk Laxatives side effects and complications?

A

Digestion by bacteria leading to flatus and bloating

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5
Q

Stool Surfactant drugs?

A

Mineral oil (eg. liquid paraffin)

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6
Q

Stool Surfactant mechanism of actions?

A
  • Decrease surface tension leading to fluid & lipid percolation
  • Lubrication leading to evacuation
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7
Q

Stool Surfactant side effects and complications?

A
  • Bad taste

* Aspiration

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8
Q

Osmotic Laxatives drugs?

A

Sorbitol, PEG

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9
Q

Osmotic Laxatives mechanism of actions?

A

Draw water into stool osmotically increasing bulk and facilitating evacuation

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10
Q

Osmotic Laxatives side effects and complications?

A
  • Hydration status

* Digestion by bacteria leading to flatus and bloating

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11
Q

Stimulant Laxatives drugs?

A
  • Bisacodyl

* Used with PEG to cleanse colon

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12
Q

Stimulant Laxatives mechanism of actions?

A
  • Stimulates peristalsis and bowel evacuation

* Rectal administration faster than oral

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13
Q

Stimulant Laxatives side effects and complications?

A

• Mild

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14
Q

Opioid Receptor Antagonists drugs?

A

Alvimopan

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15
Q

Opioid Receptor Antagonists mechanism of actions?

A

Reduce opioid induced constipation

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16
Q

Opioid Receptor Antagonists side effects and complications?

A

Possible CVS toxicity (only used inpatient)

17
Q

Chloride Channel Activator drugs?

A

• Lubiprostone

18
Q

Chloride Channel Activator mechanism of actions?

A

• Stimulates Cl- secretion into colon and causing water retention

19
Q

Chloride Channel Activator side effects and complications?

A

• Contraindicated in pregnancy

20
Q

5-HT4 Antagonists drugs?

A

Tegaserod

21
Q

5-HT4 Antagonists mechanism of actions?

A

Gastrokinetic

22
Q

5-HT4 Antagonists side effects and complications?

A

Some CVS effects

Sys Pharmaco GIT (4 decks)

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