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Sys Pharmaco GIT > Anti-Emetics > Flashcards

Anti-Emetics Flashcards

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Git Commands flashcards
1
Q

Name a major chemosensory area for

emesis:

A

Chemoreceptor trigger zone (CTZ)

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2
Q

Where is the CTZ found?

A

Area postrema of the fourth ventricle of

the brain

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3
Q

Antiemetics types?

A
  1. 5-HT3 Antagonists
  2. Corticosteroid
  3. Neurokinin Receptor Antagonists
  4. Dopamine (D2) Receptor Antag
  5. Muscarinic Antagonists
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4
Q

5-HT3 Antagonists drugs?

A

Ondansetron, -setron

• Used for acute nausea due to chemo

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5
Q

5-HT3 Antagonists mechanism of actions?

A
  • Act on ENS to increase gastric motility

* Receptors in the vomiting center are less effective

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6
Q

5-HT3 Antagonists side effects and contraindications?

A
  • Headache, dizziness
  • GIT disturbances
  • Arrhythmia
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7
Q

Corticosteroid drugs?

A

• Used for acute and chronic nausea due

to chemo

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8
Q

Corticosteroid mechanism of actions?

A

Mechanism unknown

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9
Q

Corticosteroid side effects and contraindications?

A

• Iatrongenic cushing’s in long term with adrenal

suppression

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10
Q

Neurokinin Receptor Antagonists drugs?

A

Aprepitant

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11
Q

Neurokinin Receptor Antagonists mechanism of actions?

A

Antagonism of neurokinin receptors in the chemoreceptor

trigger zone

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12
Q

Neurokinin Receptor Antagonists side effects and contraindications?

A
  • Fatigue
  • Dizziness
  • GIT disturbances
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13
Q

Dopamine (D2) Receptor Antag drugs?

A

Metaclopramide

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14
Q

Dopamine (D2) Receptor Antag mechanism of actions?

A
  • Antagonize D2 receptors in the vomiting center

* Upregulate gastric motility (gastrokinetic)

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15
Q

Dopamine (D2) Receptor Antag side effects and contraindications?

A
  • Flatus, abdominal distension
  • Parkinson’s symptoms
  • Elevated Prolactin
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16
Q

Muscarinic Antagonists drugs?

A

• Hyoscine

17
Q

Muscarinic Antagonists mechanism of actions?

A

Act on vestibular system mainly used for motion sickness

18
Q

Muscarinic Antagonists side effects and contraindications?

A

Dry mouth, blurred vision, constipation

Sys Pharmaco GIT (4 decks)

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