Latency and Tumour Viruses

Question 1

What are the different types of virally-induced tumours? What increases their incidence?

Answer 1

Lecture 19, slide 3

Question 2

What are some human tumour viruses?

Answer 2

Lecture 18, slide 4

Question 3

What are some virus-host interactions that contribute to cancer development?

Answer 3

Lecture 18, slide 5

Question 4

What type of tumour is always HHV-4 positive?

Answer 4

Lecture 18, slide 7

Question 5

What is the cause of Burkitt Lymphoma?

Answer 5

Lecture 18, slide 8

Question 6

What are Papillomaviruses? What do they cause?

Answer 6

Lecture 18, slide 9

Question 7

What are the two promoters in HPV16? What proteins does HPV make and what are some of their roles?

Answer 7

Lecture 18, slide 11

Question 8

What is the life cycle of HPV?

Answer 8

Lecture 18, slide 12

Question 9

How is cell proliferation controlled normally? How does HPV affect this?

Answer 9

Lecture 18, slide 13-14

Question 10

How does HPV cause carcinomas?

Answer 10

Lecture 18, slide 15
-development of virally-induced carcinomas takes a while because additional cellular mutations are required for malignancy to develop.

Question 11

What is the HPV vaccine made of?

Answer 11

Lecture 18, slide 18-19