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Virology > Influenza > Flashcards

Influenza Flashcards

1
Q

What are the symptoms of seasonal influenza?

A
  • headache
  • joint aches
  • vomiting
  • coughing
  • extreme tiredness
  • fever
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2
Q

Where does influenza enter the body?

A

Lecture 16, slide 7

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3
Q

What Baltimore group does influenza belong to?

A

Lecture 16, slide 9

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4
Q

What is the structure of influenza A virus?

A

Lecture 16, slide 11

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5
Q

What is the structure of vRNP?

A

Lecture 16, slide 12

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6
Q

What are the roles of the proteins encoded by the vRNA segments?

A

Lecture 16, slide 13

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7
Q

How are influenza A viruses classified? How many HA and NA subtypes are there?

A

Lecture 16, slide 14

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8
Q

What is antigenic drift and what does it cause? What is antigenic shift and what does it cause?

A

Lecture 16, slide 17

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9
Q

What is the mechanism of antigenic shift?

A

Lecture 16, slide 18-19

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10
Q

What is the pathology of H5N1 avian influenza viruses?

A

Lecture 16, slide 24-25

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11
Q

How does influenza A virus enter host cells?

A

Lecture 16, slide 28-29

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12
Q

What barrier prevents most avian influenza viruses from infecting human cells? How do pigs allow this barrier to be crossed?

A

Lecture 16, slide 30-33

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13
Q

What is the replication cycle of influenza A virus?

A

Lecture 16, slide 28

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14
Q

How is vRNP released from host cell endosomes? How can this process be therapeutically targetted?

A

Lecture 16, slide 34-39

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15
Q

How does influenza A viral RNA transcribed and replicated? What is the structure of the viral RNA polymerase? How can the RNA polymerase be targeted therapeutically?

A

Lecture 16, slide 40-43

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16
Q

How are influenza A particles released from the host cell? How can this be therapeutically targeted?

A

Lecture 16, slide 44-45

17
Q

What is the role of NS1?

A

Lecture 16, slide 47

18
Q

What are inactivated influenza vaccines? What responses do they induce?

A

Lecture 16, slide 49

19
Q

What are live attenuated influenza vaccines? What responses do they induce?

A

Lecture 16, slide 50

20
Q

What is the traditional method of influenza A vaccine development?

A

Lecture 16, slide 51

21
Q

What is the reverse genetics method of influenza A vaccine development?

A

Lecture 16, slide 52

22
Q

How would we go about making a universal influenza A vaccine?

A

Lecture 16, slide 54

Virology (7 decks)

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