Influenza

Question 1

What are the symptoms of seasonal influenza?

Answer 1

• headache
• joint aches
• vomiting
• coughing
• extreme tiredness
• fever

Question 2

Where does influenza enter the body?

Answer 2

Lecture 16, slide 7

Question 3

What Baltimore group does influenza belong to?

Answer 3

Lecture 16, slide 9

Question 4

What is the structure of influenza A virus?

Answer 4

Lecture 16, slide 11

Question 5

What is the structure of vRNP?

Answer 5

Lecture 16, slide 12

Question 6

What are the roles of the proteins encoded by the vRNA segments?

Answer 6

Lecture 16, slide 13

Question 7

How are influenza A viruses classified? How many HA and NA subtypes are there?

Answer 7

Lecture 16, slide 14

Question 8

What is antigenic drift and what does it cause? What is antigenic shift and what does it cause?

Answer 8

Lecture 16, slide 17

Question 9

What is the mechanism of antigenic shift?

Answer 9

Lecture 16, slide 18-19

Question 10

What is the pathology of H5N1 avian influenza viruses?

Answer 10

Lecture 16, slide 24-25

Question 11

How does influenza A virus enter host cells?

Answer 11

Lecture 16, slide 28-29

Question 12

What barrier prevents most avian influenza viruses from infecting human cells? How do pigs allow this barrier to be crossed?

Answer 12

Lecture 16, slide 30-33

Question 13

What is the replication cycle of influenza A virus?

Answer 13

Lecture 16, slide 28

Question 14

How is vRNP released from host cell endosomes? How can this process be therapeutically targetted?

Answer 14

Lecture 16, slide 34-39

Question 15

How does influenza A viral RNA transcribed and replicated? What is the structure of the viral RNA polymerase? How can the RNA polymerase be targeted therapeutically?

Answer 15

Lecture 16, slide 40-43

Question 16

How are influenza A particles released from the host cell? How can this be therapeutically targeted?

Answer 16

Lecture 16, slide 44-45

Question 17

What is the role of NS1?

Answer 17

Lecture 16, slide 47

Question 18

What are inactivated influenza vaccines? What responses do they induce?

Answer 18

Lecture 16, slide 49

Question 19

What are live attenuated influenza vaccines? What responses do they induce?

Answer 19

Lecture 16, slide 50

Question 20

What is the traditional method of influenza A vaccine development?

Answer 20

Lecture 16, slide 51

Question 21

What is the reverse genetics method of influenza A vaccine development?

Answer 21

Lecture 16, slide 52

Question 22

How would we go about making a universal influenza A vaccine?

Answer 22

Lecture 16, slide 54