Last Chnace Zzz Flashcards

1
Q

% of patient developing agranulocytosis in the first year

Percentage of ppl developing neutropenia

A
  1. 2%

1. 5-3%

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2
Q

% of fetal malformation with sodium valproate

A

7%

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3
Q

Trazodone can cause sedation by

A

Alpha adrenergic

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4
Q

Compliance intervention is best in

A

cognitive motivational intervention

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5
Q

Which of the following antipsychotics is recommended for mixed affective states in bipolar disorder

A

Olanzapine

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6
Q

Acamprosate is a

A

NOn competitive NMDA blocker

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7
Q

Unemotional traits heritability is

A

30-40%

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8
Q

Which of the following types of chromosomes undergo Robertsonian translocation

A

Acricentric

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9
Q

Which brain structure is spared during normal aging

A

Cranial nerve nuclei

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10
Q

Somatosensory dendritic inhibition of 5HT release is regulated by

A

5HT-1A receptors

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11
Q

CCK can be used in

A

Bulimia

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12
Q

CJD, amyloid plaque can be seen in which part of the brain

A

Cerebellum

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13
Q

Adult pattern of sleep develop in a child in

A

3 months

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14
Q

Wad is procyclidine

A

Anticholinergic drugs

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15
Q

How to change from paroxetine to fluoxetine

A

Withdraw the first and start the second immediately after stoping it

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16
Q

What study investigate whether familial data for a disorder or trait suggests any particular modes of inheritance.

A

Segregation study

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17
Q

What is Benton test

A

used for individuals aged 8 onwards to measure visual perception and visual memory. It can also help evaluating possible learning disabilities. The subject is asked to draw from memory each one of the ten designs that are shown one at a time.

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18
Q

Most common optic nerve palsy in alcoholic is….

A

6th cranial nerve

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19
Q

Which of the following psychotropics has a tendency to reduce gastrointestinal transit with a resultant slow absorption when given orally?

A

Amitriptyline

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20
Q

Pimozide cause wad special side effect

A

Ventricular problems, sudden cardiac death

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21
Q

What can cause severe rebound

A

Clonidine

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22
Q

Tom is a 10-year-old boy with Tourettes’ syndrome. He has had a medication for treating his condition, which has lead to significant weight gain. Choose the best alternative

A

Clonidine

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23
Q

Risk of ADHD in first degree relative

Second

A

15-60% 2-6 risk

Second degree 3-9%
0.5-0.8 relative rick

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24
Q

Specific phobia increase relative risk in ? Time

A

4

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25
Q

Wad chromosome has things to do with alcohol dependence

A

Chromosome 4 GABRA2

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26
Q

Unipolar depression proband

% for offspring for unipolar and bipolar

A

Unipolar x 2 for offspring 16%

Bipolar 4 fold 4%

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27
Q

Bipolar proband

% for offspring for unipolar and bipolar

A

2-3 for unipolar (16%)

Bipolar 8-9 fold (9%)

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28
Q

Which gene in Parkinson can cause early onset

A

PINK1

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29
Q

FTD is wad gene

A

Tau at chromosome 17

Progranulin

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30
Q

What is the most common psychiatric disorder in children with mild learning disability?

A

Conduct disorder

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31
Q

When some one can copy a diamond

A

Year 6

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32
Q

When some one can copy a circle

A

2-3 years (30 months)

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33
Q

Hyperhomocysteinemia

Increased risk in

A

Dementia

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34
Q

Nicotinic acide deficiency can see wad (name 4)

A

Glossitis, diarrhoea, insomnia, dermatitis, disturbed mental function

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35
Q

Ego Defence for phobia is

A

Displacement

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36
Q

The process which leads to the transfer of information from short-term memory to long-term memory is calle

A

Consolidation

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37
Q

Linguistic relativity hypothesi is wad. And by whom

A

Worfian

places language as primary and thoughts as secondary.

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38
Q

peripheralism language is by who and wad is it

A

John Watson postulated that thinking occurs peripherally in the speech apparatus

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39
Q

Drepression on ego stuff

A

Regression

Introjection

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40
Q

Wad psychobiological model of personality includes four dimensions of temperament

Whichfour

A

Cloninger’s

(1) Novelty-seeking (includes frustration avoidance, impulsive decision-making)
(2) Harm-avoidance (pessimistic worry about the future, passive avoidant behaviour, fear of uncertainty);
(3) Reward-dependence (sentimentality, social attachment, and dependence on praise and approval)
(4) Persistence (high perseverance and tolerance of frustration). The character dimensions are self-directedness, cooperativeness, and self-transcendence.

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41
Q

Who coined the term neurasthenia

It is Stress of wad

A

Beard

Urbanisation Lolz

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42
Q

Herpes encephalitis shows…

A

Presence of lymphocytic pleiocytosis with many red cells in the CSF, along with hyperintense appearance of left temporal lobe in T2 weighted MRI imaging and lateralised periodic discharges in EEG in a semi-conscious patient suggests

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43
Q

Huntington shows wad in MRI

A

Degeneration of striatum including caudate nucleus

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44
Q

Name symptoms of cannabis [

A

lethargy, apathy, loss of interest, anergia, reduced drive and lack of ambition, which is collectively known as the amotivational syndrome

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45
Q

Wad drugs can cause flashback phenomenon.

A

LSD

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46
Q

What is zar

A

where subjects present with an experience of spirit possession. Symptoms may include “dissociative episodes with laughing, shouting, hitting the head against a wall, singing, or weeping”. Individuals may show withdrawal, refusing to eat or carry out daily tasks, or may develop a long-term relationship with the possessing spirit.

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47
Q

What is so special about adenbrook’s test

A

score less than 82 has a high specificity for dementia Correct

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48
Q

Cataplexy is common in

A

Neuro stuff

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49
Q

What is bee or sign

A

Weakness of lower abdominal muscle

Spinal cord injury between T9 and T10

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50
Q

Paranoid delusions defence mechanism

A

projection

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51
Q

Foundation of school behaviourism de person is

A

John Watson

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52
Q

Who is the Father of Analytical psychology

A

Carl Gustav Jung

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53
Q

Who wrote a secure base

A

BOWbly

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54
Q

Multiple scelerosis sign in MRI

A

Hypointense lesion in corpus callosum

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55
Q

Damage of which lobe will cause nominal aphasia

A

Parietal

56
Q

Api e4 is dysfunctional at which chromosome

A

19

57
Q

Following a Robertsonian translocation in phenotypically normal individual which of the following types of chromosomes is produced?

How abt in downs

A

Metacentric

Arcocentric

58
Q

patients with major depressive disorders indicate that an intrinsic regulatory defect involving

A

Hypothalamus

59
Q

Microglia is wad in origin how abt the others

A

Microglia is mesodermal in origin

The rest are ectoderm

60
Q

Benzodiazepine withdrawal is associated with:

A

Brain GABA function decreased

61
Q

What drug are better to give pregnant ladies

A

Tricyclics and fluoxetine do not have a known teratogenic effect in humans.

62
Q

chlorthalidone, indapamide, metolazone, xipamide) are

A

Thiazide diuretics

63
Q

Datscan breakdown names are

A

Beta CIT and FP-CIT

64
Q

WaD SPECT tracer used to assess brain metabolism regionall

A

99mTc-HMPAO

65
Q

Wad is made in Adipose tissue

A

Leptin

66
Q

Carbamazepine will increase or decrease clozapine’

How about fluvoxamine

Wad antibiotic affects it as well

A

Decrease

Fluvox increases

Ciprofloxacin increaes du

67
Q

-Alpha wave is is maxiaml at ..

A

Occipital region

68
Q

Vermis of cerebellar is supply by

A

posterior inferior cerebellar artery

69
Q

Nausea and vomiting most associated drugs are

A

Aripiprazole

70
Q

Wad can cause postural hypotension

A

Clozapine and risperidone

71
Q

Constipation & Paralytic Ileu mainly associated with

A

Clozapine

72
Q

Attachment become evident during

A

8 months

73
Q

Vortioxetine works on

A

5HT3 antagonist

With 5HT 1D and 5HT 7 all antagonist

Agonist 5HT1A

Partial agonist 5ht1B

74
Q

Mid life is a myth

Coined by

A

Elliot Jacque

75
Q

Hunter syndrome is a wad transmission

3 symptoms
3 facial stuff

A

X link recessive
Symptoms: ear infection, runny noses and abdominal hernia

Facial: coarse features flattened bridge of nose, enlarged tongue

76
Q

What area of the brain is involved in depression

A

Anterior cingulate cortex

77
Q

Risk of SIADH name 3

A

Female, Low BMI, old age, use of diuretics

78
Q

Agranulocytosis risk involve

A

Increasing age, woman, ethnicity

Apparently Low baseline white cell count is associated with neutropenia and not agranulocytosis.

79
Q

phrmacodynamic wad are the terms tat are associated with it

A

Agonism, receptor half-life, occupancy, dose-response relationship are pharmacodynamic concepts.

80
Q

Moderate effects on qtC

A

Citalopram and quetiapine

81
Q

No effect on QTC

A

Mirtazapine and aripiprazole

82
Q

4 risk of child abuse

A

1) young age
2) history of parental substance abuse
3) persistent crying
4) younger age

83
Q

Who propose cognitive emotional process

A

Alfred Adler

84
Q

What is Barnum effect

A

psychological phenomenon whereby individuals will give high accuracy ratings to descriptions of their personality that supposedly are tailored specifically to them but that are, in fact, vague and general enough to apply to a wide range of people.

85
Q

According to community surveys, which of the following is the most common cause of hallucinations?

A

Sleep disorder

86
Q

.Which of the following techniques is employed in the assessment of temporal course of improvement of symptoms in patients with both PTSD and substance misuse?
Name 4

A

Impact of event scale, Clinician Administered PTSD scale, Civilian Mississippi scale for PTSD and Time Line follow

87
Q

Internal salience’ is a concept in psychology relating to cognitive processe

A

Self-motivated desire for an object or action

88
Q

PSeudocholinesterase deficiency is associated with increased sensitivity of wad chemicals

A

Donepezil

89
Q

Social capital is

A

Individuals acting co-operatively in transactions

90
Q

One Types of suicide as described by Durkheim

A

1) egoistic suicide- due to prolonged sense of not belonging , no friends
Mostly among unmarried people (men)

91
Q

Cognitive dissonance is often see as

A

Holding mutually exclusive beliefs about an object or person.

92
Q

Ecstasy

How does it work

A

1) like LSD causes serotonin release
2) like amphetamines causes dopamine release
3) blocks 5HT, noradrenaline, dopamine reuptake
4) reduction in serotonin levels in days after use hence depressive
Low addiction profile

93
Q

Wad stuff can pass through blood brain barrier

A

Small, lipophilic, unionised

Dopamine cuz they hav a special transmitter

94
Q

Serotonin thought to be an important neurotransmitter in the aetiology and treatment of mental disorder. Which of the following enzymes are not involved in its metabolism?

A

MAO, Aldehyde dehydrogenase, DOPA decarboxylase, Tryptophan hydroxylase.

95
Q

Half lifer of duloxetine

A

12 hours

96
Q

For bipolar how many percentage of people will relapse within 2 years

A

50%

97
Q

Clozapine should b avoide in prescribing

A

Carbamazepine and MAOI (can potentially increase CNS effects )

98
Q

Weight gain in antipsychotics is more significant in

A

Children and adolescent

99
Q

Which anxiety disorder can hav anticipation?>

A

OCD

100
Q

Pharmacokinetic wad are the terms that can be sue

A

Absorption, distribution, metabolism and excretion. Agonism, half-life, dose-response relationship and chelation are pharmacodynamic concepts.

101
Q

What is construct validity

A

extent to which operationalization of a construct (e.g. practical tests developed from a theory) measures a construct as defined by a theory

102
Q

Internal validity

A

is an inductive estimate of the degree to which conclusions about causal relationships can be made (e.g. cause and effect), based on the measures used, the research setting, and the whole research design.

103
Q

5 therapeutic factors of group therapy

A

universality, altruism, instillation of hope, imparting information, corrective recapitulation of the primary family experience, development of socializing techniques, imitative behaviour, cohesiveness, existential factors, catharsis, interpersonal learning, self-understanding.

104
Q

Caffeine usually Attack which receptors

A

Adenosine receptors

105
Q

Which antiantileptic has problems with outbursts in children

A

Vigabatrin

106
Q

CAMCOG is

A

The CAMCOG is the cognitive and self-contained part of the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX).

67 items

107
Q

When kids understand joke

A

6-7 years old

108
Q

When children start using 3-4 words Sentence

A

2-3 years

109
Q

R.E.M. Sleep behaviour usually arise by when (which part of sleep)

Name 3 diseased tat it is associated with

A

middle to latter third of the night during REM sleep

LBD, PD, multiple system atrophy and GB

110
Q

Diagnostic feature of Tourette’s

A

Motor and 1 or more Vocal tics
Occur many times a day nearly every day more than 1 year (no tic free for more than 3 months)
Before age 18

If only ether one motor or vocal then is chronic motor or vocal tic disorder

111
Q

Who describe disorganised schizophrenia / hebephrenic schizophrenia

A

HECKER

112
Q

Stimulants can hav wad presentation

A

Many users experience insomnia and anorexia, and some may develop psychotic symptoms. Stimulants have peripheral cardiovascular activity, including increased blood pressure and heart rate.

113
Q

In a malnourished patient with long standing alcohol use, which of the following complications could worsen on immediate refeeding with a glucose rich infusion?

A

Thiamine deficiency

114
Q

Paraphrasing is

A

Using approximate language

115
Q

FUndamental psychopathology in Caprags delusion is

A

Reduplicative paramnesia

Misidentification phenomenon where simultaneous duplication of a place, a person, or even one’s self

116
Q

Name 5 neurotic Defence

A

Intellectualisation, repression, displacement, reaction formation, and dissociation are called neurotic defences.

117
Q

two-factor theory of intelligence is wad and by whom

A

Spearman carried out a factor analysis of the result of children’s performance on a number of tests and concluded that all tests measured both a common factor of general intelligence (g) and a specific factor (s). He believed that individual differences were due to differences

118
Q

Social role valorisation is best described as

By who

A

Wolf Wolfensberger as the successor to the principle of normalization that deals with the enablement, establishment, enhancement, maintenance, and/or defense of valued social roles for people. SRV is primarily a response to the historically universal phenomenon of social devaluation and especially societal devaluation.

The correct answer is: Social acceptance of people with disabilities without devaluation

119
Q

5 factors of causing language delays

A
  • smoking in pregnancy
  • consumption of alcohol in pregnancy
  • behaviour problems in the child
  • inadequate cognitive stimulation
  • BIg family size
120
Q

Wad are universal prevention

A

Universal prevention: directed to a general population group (poor ppl)

Indicated intervention: targets high risk individuals with minimal but detectable signs

Selective interventions: to individuals or subgroups whose risk of developing disorder is significantly higher than average

121
Q

4 proposed endophenotypes in anorexia nervosa

A

Abnormal fear conditioning
Set shifting impairments
Weak central coherence
Reward sensitivity

122
Q

Genome wide association studies in schizophrenia suggest an association with which of the following genetic polymorphisms

A

Zinc Finger 804A gene

123
Q

Which of the following regions when surgically stimulated can alleviate pain

A

Periaqueductal grey

124
Q

The sensory cortex is located in the

A

Posterior cortex

125
Q

Nondeclarative memory

A

Striatum, cerebellum and neocortex with amygdala

126
Q

Endoscope does

A

Transport of cellular substances

127
Q

MAO-A metabolizes

A

Noradrenaline, 5-HT and tyramine

128
Q

Which of the following enzymes in the monoamine synthetic pathway is largely restricted to adrenal medulla?

A

Phenylethanolamine-N- methyltransferase

129
Q

administered morphine for analgesia, which of the following mechanism could explain the action?

A

Release of histamine

130
Q

Synthesis and storage of noradrenaline can be prevented by which of the following

A

Reserpine prevents the synthesis and storage of norepinephrine in sympathetic nerve terminals

131
Q

Impulsive aggression is related to a disruption in which of the following neurotransmitter systems

A

Serotonin

132
Q

What has a higher likelihood of causing peripheral neuropathy than other antidepressants

A

Phenelzine

133
Q

Which of the following is a well-documented teratogenic effect that occurs when using SSRIs in the second trimester of pregnancy?

A

Pulmonary hypertension - 3%

Worse in paroxetine

134
Q

What effect does carbamazepine have on cardiac function

A

reducing atrioventricular cardiac conduction

135
Q

The site of action of thyroid hormones is at the level of;

A

Nucleus

136
Q

Which of the following is the most important property of a depot antipsychotic medicatio

A

Presence of a carboxyl ester

137
Q

Wad can u see for acetylcholinesterase inhibitor for dementia in ECG

A

P-R interval of 280ms