Large Intestine Pharmacology Flashcards
1
Q
What are opiates used for in the GI system?
A
To treat diarrhoea
2
Q
How do opiates work?
A
Inhibit enteric neurones by hyperpolarization via activation of N-opioid receptors
3
Q
What do opiates do to peristalsis?
A
Decrease it
4
Q
What do opiates do to segmentation?
A
Increase it
5
Q
What do opiates do to fluid absorption?
A
Increase it
6
Q
Give some examples of opiates used as anti-diarrhoeal drugs.
A
Codeine, loperamide
7
Q
What do purgatives treat?
A
Constipation
8
Q
In what type of patients are purgatives used?
A
To clear bowels before surgery, in elderly severly constipated patients, or in patients with angina or haemorrhoids
9
Q
In what circumstance may purgatives be abused?
A
Eating disorders
