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GI Pharmacology > Drug Classes that Influence Acid Secretion > Flashcards

Drug Classes that Influence Acid Secretion Flashcards

1
Q

What is omeprazole an example of?

A

A PPI

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2
Q

How do PPIs block?

A

covalent modification

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3
Q

What do NSAID block and is it reversible or irreversible?

A

cyclo-oxygenase, irreversibly

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4
Q

Do H2 receptor antagonist block competitively or non competitively?

A

competitively

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5
Q

What is pirenzepine an example of?

A

Muscarinic receptor antagonist

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6
Q

What do muscarinic receptor antagonists involved in influencing acid secretion block?

A

ACh competitively on M1 and M3

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7
Q

What do NSAIDs do to prostaglandin formation?

A

reduce it

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8
Q

How can gastric damage due to a long term NSAID treatmend be prevented?

A

with a stable PGE1 analogue e.g. misoprostol

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9
Q

How does drug treatment of peptic ulcers aim to promote ulcer healing?

A

reducing acid secretion, increasing mucosal resistance and eradicating H.Pylori

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10
Q

What is an example of a condition with acid hypersecretion?

A

Zollinger-Ellison Syndrom or CUshing’s ulcers

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11
Q

What is Zollinger Ellison Syndrome?

A

rare gastrin producing tumour

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12
Q

What is Cushing’s ulcers?

A

heightened vagal tone

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13
Q

What do PPIs inhibit?

A

active H+/K+ dependent ATPase proton pump

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14
Q

Are pumps in tubulovesicles inhibited?

A

No

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15
Q

Are PPIs prodrugs?

A

yes

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16
Q

When are PPIs active?

A

inactive at neutral pH, become active in strongly acidic environment e.g. caniculus

17
Q

Do PPIs inhibit all available pumps?

A

Yes

18
Q

Does inhibition of acid secretion exceed plasma hald life?

A

Yes greatly (except in tentroprazole)

19
Q

How are PPIs administered?

A

orally once a day

20
Q

What problem might occur at night with PPIs?

A

nocturnal acid breakthrough

21
Q

Is the full effect of a PPI achieved without repeated dosing?

A

No

22
Q

How are H2 receptor antagonists administered?

A

orally once or twice a day

23
Q

What is pirenzipine an example of?

A

A muscarinic ACh receptor antagonist

24
Q

Are muscarinic Ach receptor antagonists used nowadays?

A

No

25
Q

Are gastrin receptor antagonists eg prolgomide used clinically?

A

No

26
Q

What do mucosal strengtheners require?

A

acidic environments

27
Q

How do mucosal strengtheners work?

A

bind to ulcer base and form complex gel with mucus

28
Q

What is bismuth chelate toxic to?

A

H. Pylori

29
Q

What does the antacid Mg triscilicate form?

A

MgCl2 and colloidal silical (which binds pepsin)

30
Q

What do magnesium salts cause?

A

diarrhoea

31
Q

What is the combination therapy used to treat a peptic ulcer?

A

omeprazole + clarithromycin + either amoxycillin OR metronidazole

32
Q

What type of drugs are domperidone and metroclopramide?

A

Pro motility drugs

GI Pharmacology (4 decks)

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