Drug Classes that Influence Acid Secretion Flashcards

1
Q

What is omeprazole an example of?

A

A PPI

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2
Q

How do PPIs block?

A

covalent modification

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3
Q

What do NSAID block and is it reversible or irreversible?

A

cyclo-oxygenase, irreversibly

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4
Q

Do H2 receptor antagonist block competitively or non competitively?

A

competitively

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5
Q

What is pirenzepine an example of?

A

Muscarinic receptor antagonist

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6
Q

What do muscarinic receptor antagonists involved in influencing acid secretion block?

A

ACh competitively on M1 and M3

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7
Q

What do NSAIDs do to prostaglandin formation?

A

reduce it

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8
Q

How can gastric damage due to a long term NSAID treatmend be prevented?

A

with a stable PGE1 analogue e.g. misoprostol

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9
Q

How does drug treatment of peptic ulcers aim to promote ulcer healing?

A

reducing acid secretion, increasing mucosal resistance and eradicating H.Pylori

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10
Q

What is an example of a condition with acid hypersecretion?

A

Zollinger-Ellison Syndrom or CUshing’s ulcers

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11
Q

What is Zollinger Ellison Syndrome?

A

rare gastrin producing tumour

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12
Q

What is Cushing’s ulcers?

A

heightened vagal tone

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13
Q

What do PPIs inhibit?

A

active H+/K+ dependent ATPase proton pump

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14
Q

Are pumps in tubulovesicles inhibited?

A

No

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15
Q

Are PPIs prodrugs?

A

yes

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16
Q

When are PPIs active?

A

inactive at neutral pH, become active in strongly acidic environment e.g. caniculus

17
Q

Do PPIs inhibit all available pumps?

18
Q

Does inhibition of acid secretion exceed plasma hald life?

A

Yes greatly (except in tentroprazole)

19
Q

How are PPIs administered?

A

orally once a day

20
Q

What problem might occur at night with PPIs?

A

nocturnal acid breakthrough

21
Q

Is the full effect of a PPI achieved without repeated dosing?

22
Q

How are H2 receptor antagonists administered?

A

orally once or twice a day

23
Q

What is pirenzipine an example of?

A

A muscarinic ACh receptor antagonist

24
Q

Are muscarinic Ach receptor antagonists used nowadays?

25
Are gastrin receptor antagonists eg prolgomide used clinically?
No
26
What do mucosal strengtheners require?
acidic environments
27
How do mucosal strengtheners work?
bind to ulcer base and form complex gel with mucus
28
What is bismuth chelate toxic to?
H. Pylori
29
What does the antacid Mg triscilicate form?
MgCl2 and colloidal silical (which binds pepsin)
30
What do magnesium salts cause?
diarrhoea
31
What is the combination therapy used to treat a peptic ulcer?
omeprazole + clarithromycin + either amoxycillin OR metronidazole
32
What type of drugs are domperidone and metroclopramide?
Pro motility drugs