GI Motility Drugs Flashcards
In what 3 ways should peptic ulcers be treated?
- By reducing acid secretion
- By increasing mucosal resistance
- By eradicating H. Pylori
What are the 4 drug types which reduce acid secretion and which of the four is not used clinically?
- PPIs
- H2 Receptor Antagonists
- M1 and M3 ACh receptor antagonists
- Gastrin receptor antagonists (Not used clinically)
What class of drugs is used for Zollinger-Ellison Syndrome?
PPIs
What is inhibited in the action of PPIs?
active membrane-inserted H+/K+ ATPase pump (pumps in tubulovesicles not inhibited)
When and how do PPIs become activated?
Inactive at neutral pH, change conformation in strongly acidic environment
What are PPIs activated into?
a sulfenamide
What are domperidone and metroclopramide used for?
GORD (they increase motility)
Give an example of H2 Receptor antagonist.
Ranitidine, cimetidine
What are H2 receptor antagonists used for?
peptic ulcer and GORD treatment
How do H2 receptor antagonists block H2 receptors?
Competitively, reversibly
What is the eradication therapy for H.Pylori?
Omeprazole, clarithromycin and either amoxycillin OR metronidazole
What class of drug are sucralfate and bismuth chelate?
Mucosal strengtheners
What is sucrulfate made of?
Sulphated sucrose and AlOH
How do mucosal strengtheners work?
Bind to ulcer base, and form complex gels with mucus
What do mucosal strengtheners do to mucosal blood flow?
Increase
