Large animal models Flashcards
1
Q
Name advantages of using large animals as models
A
- outbred
- repeated blood samples possible
- tissue biopsies
- longer life-span
- similar size to that of humans
2
Q
Name disadvantages of large animal models
A
- outbred
- expensive
- limited number of animals for practical and economical reasons
- handling can be cumbersome
3
Q
Where can you sample blood from pigs?
A
- jugular vein
- ear vein
- mammary vein
- retroorbital plexus
4
Q
Name three different pig/swine kinds
A
- Yorkshire (pointy ears standing up)
- Hampshire (belt)
- landrace (ears hang down)
5
Q
Why do you use minipigs for long-term studies?
A
They don’t grow that big
6
Q
What are Göttingen minipigs bred from?
A
minnesota minipig + vietnamese pig + landrace
7
Q
What are the 3 As in pig research?
A
- Acclimatisation
- Analgesia and Anaesthesia
- Aseptic procedures
8
Q
What are dogs used for in research?
A
- test new pharmaceuticals
- toxicity - non-rodent model
- surgery - transplantation
- insulin 1920s breakthrough
- Gi tract
- new vaccines for dogs
- dentistry
9
Q
Where are cat models used?
A
- CNS
- neurology
- opthalmology
10
Q
Research on primates
A
- HIV
- transplantation
- ophtalmology
- PET
11
Q
Research areas that use rabbits
A
- orthopedics
- osseointegration
- ophtalmology
- antibody production
