lambert-eaton syndrome Flashcards
1
Q
what is lambert-eaton syndrome associated with
A
small cell lung cancer
breast and ovarian cancer
also independently as autoimmune
2
Q
what causes lambert eaton syndrome
A
antibody directed against presynaptic voltage-gated calcium channel in the peripheral nervous system
3
Q
features of lambert-eaton syndrome
A
repeated muscle contractions lead to increased muscle strength (stronger the more they move)
limb-girdle weakness
hyporeflexia
autonomic: dry mouth, impotence, difficulty micturating
4
Q
diagnosis of lambert eaton syndrome
A
EMG
calcium channel gate?
5
Q
management of lambert-eaton syndrome
A
treat underlying
immunosuppression- prednisolone or azathioprine
