lactation Flashcards
three stages of lactation n
- Mammogenesis
- Lactogenesis
- Galactopoiesis
Mammogenesis requires what hormone
mammary growth development
Requires estrogen and progesterone
lactogenesis -requries
initiation of milk secretion
a. Requires prolactin
galactopoiesis what is it and what does it require
maintenance of milk secretion
Requires prolactin, oxytocin (released during suckling)
The more baby suckles, the more milk production
Involution
– when mom stops breastfeeding
typical breast increase
Increase in breast size (gain 400g each)
physiological breast changes
cell types, ducts, lobes
Formation of new mammary ducts
Development of lobular architecture
Epithelium differentiates for secretory activity
lactations is initiated when …
Lactation is initiated when plasma estrogens, progesterones, and human placental lactogen levels fall after delivery
may be delayed during c section
prolactin levels will return to nonpregnant level in the absence of suckling in __
e. Prolactin levels will return to nonpregnant level in the absence of suckling 2-3 weeks postpartum
Maintenance of established milk secretion requires suckling and the emptying of mammary ducts and alveoli
Takes a few days for the milk to “come in”
Newborns can suckle almost every 30 mins
Premilk secretion present in the first ___ postpartum
Premilk secretion present in the first 2-3 days postpartum before milk comes in
may begin in the last week sof pregancny
normal weight loss and when do they get it back
babies can lose 10% in the first week
and should gain back normal birthweight in two weeks
“liquid gold”
collostrum
Yellowish alkaline secretion
super concentrated
high in protein, vitamins, immuno globulins
lower carb, K, and fat than breast milk
normal laxative action for meconium
moves through the gut quicker
what drives milk production
Prolactin drives milk production
Other hormones involved (insulin, cortisol, etc)
Substrates for milk are derived from the ___ and ____
ii. Substrates for milk are derived from the maternal gut and liver
calorie intake during lactation needs to be around____
500 calories to sustain milk production
needs to be fat and protein rich
what is the nutrition make up of breast milk
how many calories
Mature human milk contains 7% CHO as lactose, 3-5% fat, 0.9% protein, minerals, vitamins, enzymes, and water
- 60-75 kcal/dL provided to the infant
- In a healthy mom producing breast milk, breast milk should be the only thing the baby needs for the first 6 months of life
transfer of immunoglobulins
is highest when…
what type of immunoglobulins are most common
Maternal transfer of immunoglobulins through breast milk provides immunologic defense for the newborn as the immune system develops
- Highest output during the first week
- All classes of immunoglobulins in breast milk
a. 90% IgA
what is meant by highly anti-infective
Breast milk is also highly anti-infective
a. Primarily leukocytes
b. If mom is sick and is producing antibodies, those antibodies will be transferred to the baby as well
average milk production
Average milk production in a breastfeeding mother is 120 mL by the second postpartum day and increases to 300 mL/d by postpartum days 10-14
how does the CNS improve milk output
increases oxytocin with support
ways to increase milk production
Nurse more often (the best way)
Pump between feedings
(pumping is not as efficient as suckling)
Herbal supplements
Metoclopramide (Reglan) 10mg BID off-label use