lab values, drug monitoring and patient charts

Question 1

leukopenia

Answer 1

low WBC count

Question 2

leukocytosis

Answer 2

high WBC count

Question 3

average lifespan of RBCs

Answer 3

120 days

Question 4

Erythrocytosis

Answer 4

high RBC count

Question 5

average lifespan of platelets

Answer 5

7-10 days

Question 6

thrombocytosis

Answer 6

high platelet count

Question 7

thrombocytopenia

Answer 7

low platelet count

Question 8

amikacin therapeutic drug level

Answer 8

peak: 10-40 mcg/ml, trough:

Question 9

carbamazepine TDM (usual range)

Answer 9

4-12 mcg/mL

Question 10

digoxin TDM (usual range)

Answer 10

Afib - 0.8-2

heart failure 0.5-0.9

Question 11

gentamicin TDM (usual range)

Answer 11

peak: 5-10
trough:

Question 12

lithium TDM (usual range)

Answer 12

0.6-1.2 (up to 1.5 for acute symptoms)

Question 13

enoxaparin TDM

Answer 13

VTE tx with daily therapy: 1-2 anti-Xa units/mL
VTE tx with Q12h therapy: 0.6-1 anti-Xa units/mL
recurrent VTE prophylaxis in pregnancy: 0.2-0.6 anti-Xa units/mL

Question 14

phenobarbitial/primidone TDM

Answer 14

20-40 mcg/ml

Question 15

phenytoin/fosphenytoin TDM

Answer 15

10-20 mcg/ml - if albumin is low, correct serum level

Question 16

free phenytoin TDM

Answer 16

1-2.5 mcg/ml

Question 17

procainamide TDM

Answer 17

4-10 mcg/ml

Question 18

NAPA TDM

Answer 18

15-25 mcg/ml

Question 19

procainamide + NAPA TDM

Answer 19

10-30 mcg/ml

Question 20

theophylline TDM

Answer 20

5-15 (5-10 in neonates)

Question 21

tobramycin TDM

Answer 21

peak: 5-10

trough

Question 22

Valporic Acid TDM

Answer 22

50-100 ( up to 150 in some patients); is low albumin, correct serum level

Question 23

vancomycin TDM

Answer 23

trough: 15-20 if serious infection (10-15 for others)

Question 24

warfarin

Answer 24

goal inr: 2-3 (2.5-3.5 with mechanical mitral valves)