Dyslipidemia Flashcards
Goal Non-HDL
Goal LDL
Goal HDL
Men >40
Women >50
Goal triglycerides
LDL =
TC-HDL-(TG/5)
TG MUST BE FASTING
APo-a
HDL
Apo-b
Non HDL
LDL
When is treatment recommended
- Clinical ASCVD
- Primary elevation LDL >190
- DM and 40-75 yo w/ LDL 70-189
- 40-75 yo w/ LDL 70-189 and 10 yr risk of ASCVD >7.5%
Clinical ASCVD
ACS S/P MI stable/unstable angina Stroke TIA Peripheral arterial dz of atherosclerotic origin
Treatment: Primary ^ LDL >190
High intensity
Treatment: DM and 40-75 yo w LDL 70-189 w 10 yr risk
Moderate intensity
Treatment: DM and 40-75 yo w LDL 70-189 w 10 yr risk >/=7.5%
High intensity
Treatment: 40-75 yo w LDL 70-189 w 10 yr risk
Consider risk benefit
Treatment: 40-75 yo w LDL 70-189 w 10 yr risk >/=7.5%
Moderate-high intensity
Treatment: Clinical ASCVD = 75
High intensity
Treatment: Clinical ASCVD >75
Moderate intensity
High intensity statins and dose
Atorvastatin 40-80 qd
Rosuvastatin 20-40 qd
Moderate intensity atorvastatin
10-20
Low intensity statins
Simvastatin 10 Pravastatin 10-20 Lovastatin 20 Fluvastatin 20-40 Pitavastatin 1
Statin toxicities
Think moa: HMG CoA Reductase inhibitor
H- hepatotoxicity
M- myopathy
R - rhabdomylosis
Which statins do you dose in the pm
SAM LOATHES THE FLU
simvastatin
Lovadtatin
Fluvastatin
Most potent statin
Pitavastatin (based on potency)
Rosuvastatin (based on efficacy)
Lipitor
Atorvastatin
Zocor
Simvastatin
