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Dyslipidemia Flashcards

1
Q

Goal Non-HDL

A
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2
Q

Goal LDL

A
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3
Q

Goal HDL

A

Men >40

Women >50

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4
Q

Goal triglycerides

A
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5
Q

LDL =

A

TC-HDL-(TG/5)

TG MUST BE FASTING

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6
Q

APo-a

A

HDL

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7
Q

Apo-b

A

Non HDL

LDL

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8
Q

When is treatment recommended

A
  1. Clinical ASCVD
  2. Primary elevation LDL >190
  3. DM and 40-75 yo w/ LDL 70-189
  4. 40-75 yo w/ LDL 70-189 and 10 yr risk of ASCVD >7.5%
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9
Q

Clinical ASCVD

A 
ACS
S/P MI
stable/unstable angina
Stroke
TIA
Peripheral arterial dz of atherosclerotic origin
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10
Q

Treatment: Primary ^ LDL >190

A

High intensity

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11
Q

Treatment: DM and 40-75 yo w LDL 70-189 w 10 yr risk

A

Moderate intensity

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12
Q

Treatment: DM and 40-75 yo w LDL 70-189 w 10 yr risk >/=7.5%

A

High intensity

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13
Q

Treatment: 40-75 yo w LDL 70-189 w 10 yr risk

A

Consider risk benefit

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14
Q

Treatment: 40-75 yo w LDL 70-189 w 10 yr risk >/=7.5%

A

Moderate-high intensity

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15
Q

Treatment: Clinical ASCVD = 75

A

High intensity

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16
Q

Treatment: Clinical ASCVD >75

A

Moderate intensity

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17
Q

High intensity statins and dose

A

Atorvastatin 40-80 qd

Rosuvastatin 20-40 qd

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18
Q

Moderate intensity atorvastatin

A

10-20

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19
Q

Low intensity statins

A 
Simvastatin 10
Pravastatin 10-20
Lovastatin 20
Fluvastatin 20-40
Pitavastatin 1
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20
Q

Statin toxicities

A

Think moa: HMG CoA Reductase inhibitor

H- hepatotoxicity
M- myopathy
R - rhabdomylosis

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21
Q

Which statins do you dose in the pm

A

SAM LOATHES THE FLU

simvastatin
Lovadtatin
Fluvastatin

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22
Q

Most potent statin

A

Pitavastatin (based on potency)

Rosuvastatin (based on efficacy)

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23
Q

Lipitor

A

Atorvastatin

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24
Q

Zocor

A

Simvastatin

25
Q

Vytorin

A

Simvastatin and ezetimibe

26
Q

Crestor

A

Rosuvastatin

27
Q

Pravachol

A

Pravastatin

28
Q

Mevacor

A

Lovastatin

29
Q

Altoprev

A

Lovastatin

30
Q

Advicor

A

Lovastatin+niacin

31
Q

Atorvastatin 10 = Simvastatin

32
Q

Atorvastatin 10 = Rosuvastatin

33
Q

Atorvastatin 10 = Pravastatin

34
Q

Atorvastatin 10 = Lovastatin

35
Q

Atorvastatin 10 = Fluvastatin

36
Q

Atorvastatin 10 = Pitavastatin

37
Q

Zetia

38
Q

Welchol

A

Colesevelam

39
Q

Colesevelam moa

A

Bile acid sequestrant

40
Q

TriCor

A

Fenofibrate/fenofibric acid

41
Q

Trilipix

A

Fenofibrate/fenofibric acid

42
Q

Lopid

A

Genfibrozil

43
Q

Genfibrozil dosing

A

600 mg bid (30 min b4 breakfast and dinner)

44
Q

Contraindications to fibrates

A

Breastfeeding
Liver dz -severe (including primary biliary cirrhosis)
Gallbladder dz
Renal dz - severe

45
Q

Moderate intensity Rosuvastatin

46
Q

Moderate intensity Simvastatin

47
Q

Moderate intensity Pravastatin

48
Q

Moderate intensity Lovastatin

49
Q

Moderate intensity

Fluvastatin REG AND XL

A

XL 80

Reg - 40 BID

50
Q

Moderate intensity Pitavastatin

51
Q

Non-HDL=

52
Q

Niaspan

A

Extended release niacin

53
Q

What dosages does Niaspan come in?

A

500, 750, 1000

54
Q

Niacin aka

A

Nicotinic acid

Vit b3

55
Q

Niacin and bile acid sequestrant administration

A

Niacin 4-6 hrs after BAS

56
Q

When are fish oils indicated

A

Adjunct to diet with ppl with TG>500

57
Q

Juxtapid

A

Lomitapide

58
Q

When is Lomitapide indicated

NAPLEX (15 decks)

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