Lab Test 3- Clinical Enzymology BTs

Question 1

Lactate dehydrogenase catalyzes

Answer 1

The oxidation of L-lactate to pyruvate

Question 2

Which of the following sentences about the interpretation of a troponin test is correct:

Answer 2

It takes 2-3 hours for troponin levels to begin to rise

Troponin can remain elevated for up to 10 days, thus permitting late diagnosis

Trponin can also be used to detect reinfarction

All of the above

Question 3

Physiologically bone alkaline phosphatase (bALP) is increased in:

Answer 3

Growing children

Question 4

The mitochondrial enzymes are

Answer 4

not readily released into the circulation

Question 5

Which of the following sentences about aminotransferases are correct?

Answer 5

AST normal serum values are 0-30Ul/L

ALT normal serum values are 0-30 Ul/L

AST/ALT ratio is approximately 0.8 in normal subjects

All of the above

Question 6

Which of the following markers are elevated in prostrate cancer?

Answer 6

Acid phosphatase and Prostrate specific antigen?

Question 7

cTnT is expressed to a minor extent in

Answer 7

skeletal muscle

Question 8

How many isoenzymes of creatnine kinase exists?

Answer 8

3

Question 9

The enzyme which is small enough to pass through the kidney is

Answer 9

amylase

Question 10

Ligase activity in the serum and other body fluid is measured exclusively for

Answer 10

Pancreatic disorders

Question 11

y-glutamyltransferase(GGT) serum level is not elevated in

Answer 11

Rhabydomyolysis(muscle destruction)

Question 12

Non-enzymatic markers of myocardial damage include

or

Commonly used non enzymatic biomarkers for early detection of acute myocardial infarctions are:

Answer 12

cTnl and cTnT

Question 13

What enzyme is elevated in patients with obstructive biliary diease/Paget’s disease?

Answer 13

ALP

Question 14

Choose the correct answer for LDH isoenzymes:

Answer 14

None of the above is correct

High level of LDH is seen in teratomas

LDH 3 is predominant in the liver

LDH 1 is a marker of myocardial infarction

_{The correct answer is: <strong>LDH1 and 2</strong> are predominantly present in cardiac muscles, kidney and erythrocytes. <strong>LDH4 and 5</strong> isoenzymes are predominant in liver and skeletal muscle. <strong>LDH2, 3 and 4 </strong>are found in many other tissues like spleen, lungs, endocrine glands, platelets etc}

Question 15

Which enzyme is mainly secreted by pancreas and salivary glands?

Answer 15

Amylase

Question 16

Normal serum levels for AST (SGOT) is:

Answer 16

0-30 Ul/L

Question 17

PSA is useful for determining

Answer 17

the extent of prostrate cancer and assessing the response to prostrate cancer treatment

Question 18

Cardiac troponin is used for the diagnosis of

Answer 18

Acute myocardial infarction

Question 19

A form of enzyme called Regan’s isoenzyme produced by malignant tumors applies to

Answer 19

alkaline phosphatase

Question 20

Normal serum value for acid phosphatase is

Answer 20

0.1-0.63 Ul/L

Question 21

Which of the following is not true about liver diseases?

Answer 21

creatnine kinase level is increased in cirrhosis

Question 22

Choose the correct sentence

Answer 22

Amylase is a marker for acute pancreatitis

Question 23

Choose the correct sentence

Answer 23

Cardiac troponin I (cTnl) and T(cTnT) are better diagnostic enzymatic markers for AMI than CK-MB mass

Question 24

Which enzyme is strongly inhibited by dextrorotatory tartrate ions?

Answer 24

prostatic enzyme of acid phosphatase

Question 25

Choose the condition that can be associated with elevated aminotransferase levels:

Answer 25

adrenal insufficiency

hyperparathyroidism

celiac disease

all of the above

Question 26

Choose the correct sentence

Answer 26

Elevated creatnine kinase levels may be caused by severe alcohol withdrawal

Question 27

Choose the correct sentence about phosphatases

Answer 27

Elevated levels of acid and alkaline phosphatase are observed in Paget’s disease