Lab Test 2 : Serum Proteins Bts

Question 1

The antigen binding site is located nearby the following fragments of immunoglobulin G

Answer 1

VL and VH

Question 2

The picture shows desitometric scan of electrophoretic gel of serum proteins. Which fraction is abnormal?

Answer 2

Albumins

Question 3

Normal serum protein fractions in order from the highest concentration to the lowest is:

Answer 3

Albumins, y-globulins, B-globulins, a2 globulins, a1-globulins

Question 4

Transferin is a protein that belongs to:

Answer 4

B-globulin fraction and it is negative acute response reactant

Question 5

Which of the following diseases can be described as an X-linked disorder of copper metabolism, that affects only male infants, involes the nervous system, connective tissue and usually fatal in infancy:

Answer 5

Menkes disease

Question 6

Choose the correct sentence concerning immunoglobulins:

Answer 6

The variable end of antibody is the area that recognizes and binds to the antigen

Question 7

Choose the incorrect sentence concerning cytokines

Answer 7

Cytokines can be produced only by T cells

Question 8

Choose the incorrect sentence concerning TNF:

Answer 8

Tumor necrosis factor is cytokine responsible for the transport of several substances

Question 9

Which of the following sentences about Wilsons disease is correct:

Answer 9

Copper accumulates in liver, brain, kidney and RBCS

Serum ceruloplasmin level is reduced

Symptoms include corneal Keyser-Fleischer rings

All of the above

Question 10

The concentration of serum proteins of 94g/L is classified as

Answer 10

Hyperproteinemia

Question 11

The proper characteristic of albumin gives the answer:

Answer 11

It provides 80% of the colloid osmotic pressure. It is primary serum plasma responsible for the transport of hydrophobic free fatty acids, uncojugated bilrubin, some hormones, trace metal drugs

Question 12

Gamma-globulin contains:

Answer 12

Immunoglobulins and C-reactive protein

Question 13

IgG

Answer 13

is the most common immunoglobulin that protects tissue spaces. It circulates in plasma in high concentration accounting for 75%of immunoglobulin present in adults

Question 14

The monoclonal gammopathy

Answer 14

disorders characterized by the proliferation of single clone of plasma cells which produces an immunologically homogeneous protein

Question 15

The negative marker of the acute phase response is:

The positive marker of acute phase response is not:

Answer 15

albumin

Question 16

An increase of hs-CRP may:

Answer 16

Reflect a state of chronic low grade inflammation and is associated with an increased risk of coronary heart disease

Question 17

The detection of monoclonal antibodies is useful in the diagnosis of

Answer 17

Diverse malignant pathologiessuch as myeloma and Waldenstrom macroglobulinemia

Question 18

Gamma globulins constitute

Answer 18

12-22% of serum proteins, 0.5-1.6 g/dl protein concentration

Question 19

Globulins

Answer 19

account for about 35-48% of the total plasma protein

Question 20

Total serum protein concentration of 48g/L can be described as

Answer 20

Hipoproteinemia

Question 21

The Kayser Fleischer ring occurs in

Answer 21

Wilson’s disease

Question 22

Which of following serum proteins can be decreased during the actue phase response:

Answer 22

albumin, transferrin

Question 23

Which of following sentences about albumin is correct:

Answer 23

It is the predominant serum protein

Question 24

Alfa-2 globulins contain

Answer 24

ceruloplasmin, a2-macroglobulin and haptoglobin

Question 25

Which type of immunoglobulin is the first to be synthesized after an antigenic challenge

Answer 25

IgM

Question 26

Which of the following sentences about ceruloplasmin is correct

Answer 26

Its serum level in Wilson’s disease is low

Question 27

Normal serum protein fractions in order of fastest to slowest electrphoresis mobility are:

Answer 27

Albumins, a1-globulins, a2 globulins, B globulins, y globulins

Question 28

The most important property of interferon is

Answer 28

anti-viral action

Question 29

Interleukins are produced by:

Answer 29

T lymphocytes, antigen presenting cells, mast cells

macrophages,natural killer cells, monocytes

basophils, eosinophils, epithelial cells

All of the above

Question 30

A transient hiperproteinemia may be caused by:

Answer 30

dehydration

Question 31

The picture shows serum protein electrophoresis, it can suggest:

Answer 31

Monoclonal gammopathy

Question 32

Choose the correct statement concerning immunoglobulin structure:

Answer 32

They always contain 2 identical heavy chains(H) and 2 identical light chains

Question 33

Which of the following about serum protein electrophoresis is false:

Answer 33

Albumin has the slowest and gamma globulin fastest mobility in electrical foeld

Question 34

Hipoproteinemia reflects all of the conditions except

Answer 34

Myeloma

Question 35

Which of the following sentences about negative acute phase proteins is correct

Answer 35

they include albumin, prealbumin and transferrin

Question 36

Class of immunoglobulins are determined by

Answer 36

Heavy chain

Question 37

Alpha 1 globulins constitute:

Answer 37

Alpha 1: 2.5% -5% of serum proteins, 0.1 - 0.4g/dL concentration

Question 38

B-globulins constitute

Answer 38

8-14% serum protein, 0.5-1.1 g/dl protein concentration

Question 39

Albumins constitute

Answer 39

52 -65% serum protein, 3.2-5.6g/dl protein concentration

Question 40

Total protein concentration

Answer 40

6-8g/L serum protein concentration, 100% serum protein