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PA 2 > lab midterm > Flashcards

lab midterm Flashcards

1
Q

It is a tablet property related to hardness. It is the ability to withstand abrasion in packaging, handling and shipping.

A

FRIABILITY

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2
Q

It determines the percentage loss on tablet in packaging, handling and shipping.

A

FRIABILITY TEST

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3
Q

Makes use of a tumbling apparatus where tablets are exposed to rolling and repeated shocks from free fall within the apparatus.

A

ROCHE FRIABILATOR

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4
Q

Conditions of Roche Friabilator

A

100 REVOLUTIONS IN 4 MINUTES

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5
Q

Number of samples if weight is > 650mg per tablet

A

10 SAMPLES

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6
Q

Number of samples if weight is ≤ 650mg per tablet.

A

20 SAMPLES

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7
Q

Required weight loss percentage

A

NOT MORE THAN 1%

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8
Q

Apparatus used in weighing the samples

A

ANALYTICAL BALANCE

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9
Q

select this mode if the weight of the tablets to be entered manually

A

MANUAL

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10
Q

select this mode if the balance is connected to the instrument.

A

BALANCE

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11
Q

select this mode if the test is to be performed by setting rotation.

A

ROTATION

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12
Q

select this mode if the test is to be performed by setting the time.

A

TIMER

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13
Q

This term means actual rotations.

A

ACT ROTATION

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14
Q

Formula for % Wt. loss

A

% Wt Loss = IW - FW/ IW x 100

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15
Q

A test that measures the time required, under a given set of conditions, for a group of solid dosage forms to disintegrate.

A

DISINTEGRATION TEST

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16
Q

Based on USP definition, it is the state in which any residue of the unit, except, fragments of insoluble coating or capsule shell remaining is a soft mass having no palpably firm core.

A

COMPLETE DISINTEGRATION

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17
Q

Disintegration Apparatus

A
  1. Basket-rack assembly
  2. 1000 mL low form beaker
  3. A thermostatic arrangement for heating fluid
  4. A device for raising and lowering the basket
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18
Q

Disintegration Media

A
  1. Maintained at a temperature of 37 +_ 2C
  2. Examples: Distilled Water, Simulated Gastric Fluid TS, Simulated Intestinal Fluid TS
19
Q

Criteria for Disintegration Test

A
  • If 1 or 2 tablets fail, repeat the test using 12 additional tablets
  • Not less than 16 of the total 18 tablets should disintegrate completely
20
Q

Materials used in Disintegration Test

A
  • Disintegration apparatus
  • Distilled water
  • Uncoated tablets, Any brand
21
Q

To select the test and to start the test

A

TEST

22
Q

To validate the ROTATION/STROKE

A

VALIDATION

23
Q

To enter the current date and time

A

CLOCK SETTINGS

24
Q

To enter the product name, temperature, and alarm time

A

PRODUCT

25
Q

To print product data, test report, and validation report

A

DATA PRINTING

26
Q

Tablet hardness is also known as __

A

CRUSHING STRENGTH

27
Q

It refers to the resistance of the tablet to chipping, abrasion or breakage under conditions of storage, transportation and handling before usage.

A

HARDNESS

28
Q

The test is done by application of a load to the edges of a tablet across a diameter. The load is gradually increased until the tablet fractures or break. The value of the load at this point (crushing force) gives a measure of the hardness of the tablet.

A

HARDNESS TEST

29
Q

How many samples are used in hardness test to determine the mean value?

A

3 SAMPLES

30
Q

Mechanism of Stokes-Monsanto Hardness Tester

A

SPRING

31
Q

Mechanism of Strong Cobb Hardness Tester

A

AIR PUMP

32
Q

Mechanism of Pfizer Hardness Tester

A

HARD PLIERS

33
Q

Mechanism of Erweka Hardness Tester

A

SUSPENDED WEIGHT

34
Q

Most widely used because it eliminates the operator variability

A

SCHLEUNIGER HARDNESS TESTER

35
Q

Most primitive and practical test for hardness of tablets.

A

RULE OF THUMB

36
Q

It refers to the depth or extent from one surface to another surface.

A

TABLET THICKNESS

37
Q

Equipment used for Tablet Hardness and Thickness tests

A

VERNIER CALIPER
THICKNESS GAUGE

38
Q

Criteria for Tablet Hardness and Thickness Test

A

Average thickness ‡ 5% deviation

39
Q

Stokes-Monsanto Hardness Tester Acceptable Range for Ordinary compressed tablets

A

4 to 10 kg

40
Q

Stokes-Monsanto Hardness Tester Acceptable Range for Sublingual tablets

A

2 kg

41
Q

Stokes-Monsanto Hardness Tester Acceptable Range for Chewable Tablets

A

2 kg

42
Q

Stokes-Monsanto Hardness Tester Acceptable Range for Buccal Tablets

A

10 kg

43
Q

1.6 times better than Stokes

A

STRONG COBB HARDNESS TESTER

PA 2 (9 decks)

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