Lab 6

Question 1

C1 esterase inhibitor deficiency

Answer 1

CAuses hereditary angioedema due to unregulated activation of kallikrein - increased bradykinin, ACE inhibitors are contraindicated.

Question 2

C3 deficiency

Answer 2

Increases risk of severe, recurrent pyogenic sinus and respiratory tract infections; increased susceptibility to type III hypersensitivity reactions.

Question 3

C5-C9 Deficiencies

Answer 3

Terminal complement deficiency increases susceptibility to recurrent Neisseria bacteremia.

Question 4

What do steroids inhibit?

Answer 4

Phospholipases

Question 5

What do COX inhibit?

Answer 5

Cyclooxygenase

Question 6

What does PGI2 cause?

Answer 6

Causes vasodilation, inhibits platelet aggregation

Question 7

What does TXA2 cause?

Answer 7

Causes vasoconstriction, promotes platelet aggregation

Question 8

What do PGD2, PGE2 and PGF2 do?

Answer 8

Vasodilation, potentiate edema

Question 9

What do LXA4 and LXB4 do?

Answer 9

Vasodilation. Inhibit neutrophil chemotaxis. Stimulate monocyte adhesion.

Question 10

What do LTC4, LTD4, LTE4 do?

Answer 10

Vasoconstriction, bronchospasm, increased permeability.

Question 11

What does LTB4 do?

Answer 11

Chemotaxis for neutrophils

Question 12

Which chemicals cause microbicidal actions?

Answer 12

ROS, NO, lysosomal enzymes

Question 13

What chemicals cause pathologic inflammation?

Answer 13

IL-1, IL-12, IL-23, chemokines

Question 14

What chemicals cause anti-inflammatory effects?

Answer 14

IL-10, TGF-Beta

Question 15

What chemicals cause would repair and fibrosis?

Answer 15

Arginase, proline, polyaminases, TGF-Beta

Question 16

What are the three ways that H. pylori causes acute gastritis?

Answer 16

1. LPS induces inflammatory response
2. Increased gastric acid production
3. Decreased duodenal bicarbonate production

Question 17

Acute Endocarditis: Type of bug

Answer 17

Staph aureus (high virulence)

Question 18

Acute Endocarditis: Type of vegetations

Answer 18

Large vegetations

Question 19

Acute Endocarditis: Type of valves

Answer 19

Previously normal valves

Question 20

Acute Endocarditis: Onset

Answer 20

Rapid onset

Question 21

Acute Endocarditis: Timeline

Answer 21

Occurs within days

Question 22

Acute Endocarditis: Associated with?

Answer 22

IV drug use

Question 23

Acute Endocarditis: which side of the heart?

Answer 23

Typically right-sided heart valves

Question 24

Subacute Endocarditis: Type of bug

Answer 24

Strep viridans (low virulence)

Question 25

Subacute Endocarditis: Type of vegetations

Answer 25

Smaller vegetations

Question 26

Subacute Endocarditis: Type of valves

Answer 26

Congenitally abnormal or diseased valves

Question 27

Subacute Endocarditis: Onset

Answer 27

More insidious onset

Question 28

Subacute Endocarditis: Timeline

Answer 28

Occurs in weeks to months

Question 29

Subacute Endocarditis: Associated with?

Answer 29

Dental procedures

Question 30

Subacute Endocarditis: Side of heart

Answer 30

Typically left-sided heart valves

Question 31

The most common opportunistic infection in the US is…

Answer 31

Pneumocystis Carinii

Question 32

The most common opportunistic infection globally is…

Answer 32

Tuberculosis

Question 33

Which type of infection will have low glucose?

Answer 33

bacterial.

Question 34

Which infection looks like spaghetti and meatballs?

Answer 34

Candida pneumonia