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Pathology (Em's Notes) > Lab 5: > Flashcards

Lab 5: Flashcards

1
Q

What takes over in chronic inflammation?

A

macrophages and fibroblasts

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2
Q

IL-1 mediates

A

Fever

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3
Q

IL-2 stimulates

A

T cells

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4
Q

IL-3 stimulates

A

bone marrow

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5
Q

IL-4 stimulates

A

IgE production

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6
Q

IL-5 stimulates

A

IgA production

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7
Q

IL-6 stimulates

A

aKute-phase protein production

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8
Q

IL-8

A

major chemotactic for neutrophils

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9
Q

IL-12

A

Induces differentiation of T cells into Th1 cells. Activates NK cells

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10
Q

TNF-alpha

A

Mediates septic shock. Activates endothelium. Causes WBC recruitment, vascular leak

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11
Q

What are the chemotactic factors for neutrophils?

A 
C5a
IL-8
LTB4 
Kallikrein
\+ Bacterial breakdown products (Pathoma) 
\+ f-met-leu-phe
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12
Q

What are WBC casts in the urine characteristic of?

A

acute pyelonephritis

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13
Q

Pathogenesis of hematogenous acute pyelonephritis

A

septicemia/bacteremia

endocarditis

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14
Q

Pathogenesis of ascending acute pyelonephritis

A

Obstruction
Vesicoureteral reflux
Intrarenal reflux

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15
Q

What is the most common presentation of diverticulitis?

A

Left Lower Quadrant pain
Blood in the stool
Fever
Elevated WBC count

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16
Q

What does prostaglandin do in the stomach?

A

Increases mucous and bicarbonate production
Inhibits stomach acid secretion
Increase blood flow within the stomach wall

17
Q

How does H. pylori contribute to PUD?

A
  • LPS induces potent inflammatory and immune responses
  • Increased gastric acid production
  • Decreased duodenal bicarb production

Pathology (Em's Notes) (10 decks)

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