Lab #4 Flashcards
Interthalamic adhesion
connection bundle in the middle of the thalamus
Thalamic Tubercle
- Bump on superior anterior thalamus
- No function
Vascullar organ of lateral terminalis
Monitors CSF for salt concentration
Hypothalamus function
- Maintain homeostasis
- BP, electrolyte composition
- Body temp
- Energy metabolism
- Reproduction
- Physical, immunological stress response
- 4 F’s: feeding, fighting, fleeing, fornicating
- Sleep
- General: interface between NS and endocrine/autonomic systems
Lamina Terminalis
- Anterior end of the closed neuropore
- Runs from anterior commisure to optic chiasm

Mammillary Bodies
- Participate in memory functions
- Located at termination point of fornix
Fornix
- Connects hippocampus to mammillary bodies
- Cuts hypothalamus into medial and ventral parts
- Plays a part in memory

Lateral Hypothalamus
- Keeps you awake
- Keeps you eating
- Outputs to cerebral cortex, basal forebrain, amygdala
Tuber cinereum
- Gray matter between mammillary bodies and optic chiasm
- Contains arcuate nucleus = feeding

Uncus
- Part of the parahippocampal gyrus, on medial inferior temporal lobe
- Olfactory cortex
Insula Parts & Functions
- General: interoception (taste, temp)
- Posterior: HR, RR, bodily state
- Mid-insula: sensory reresentation of viscera
- Anterior: subjective intensity of experience (emotional level)
- Inputs to amygdala, hippocampus, anterior cingulate cortex, medial prefrontal cortex

Median Eminence
- Small swelling on tuber cinereum, posterior to infundibulum
- Circumventricular organ (no BBB)
- Major source of signaling to hypothalamus,
- AND releases hormones into bloodstream
- Release “releasing hormones” into hypothalamic-hypophyseal portal system to the anterior pituitary for various endocrine functions

Infundibulum
- Cone-shaped
- Gives rise to pituitary stalk

Hypothalamo-hypophyseal Tract
- Axons running from paraventricular nucleus and supraoptic nuclei to posterior pituitary
- Releases vasopressin (to block fluid loss)
Mammillothalamic tract
- Links mammillary bodies to anterior thalamus
- Memory
- Connects hippocampus and anterior thalamus

Preoptic Nucleus
- Set point generator

Sexually dimoprhic nuclei
- Sex behaviors
- Larger in males

Suprachiasmatic nucleus
- Circadian rhythms
- Respondible for release of melatonin

Arcuate nucleus
- In wall of tuber cinereum
- Feeding/appetite

Ventromedial Nucleus
- Superior to arcuate nucleus
- Regulates satiety/stop eating
- DAMAGE = obesity, aggression
Dorsomedial, posterior nuclei
Maturation and thermogenesis

Tubermammillary Nucleus
- Lateral hypothalamic nuclei
- Sleep/wake/circadian rhythm

Corticolimbic System Function
- Generate appropriate reactions
- Facilitate recognition
Amygdala
- Recognition of non-neutral stimuli
- Low-road input from thalamus (unprocessed)
- High-road input from cortex (processed)
Stria Terminalis
- Runs with thalamo-striate vein
- Anticipation of threat
- Outflow from amygdala to hypothalamus to basal forebrain
- Goes to anterior hypothalamus = sexual, agonistic behavior

Stria medullaris
- Outflow from basal forebrain and hypothalamus to habenula

Substantia Innominata
- NBM + BNST
- NBM = synthesizes ACh for arousal
- BNST = detect potential threat (CeA)
Ventromedial Prefrontal Cortex
- VALENCE center
- Receives input from BLA, NBM
- Damage = abulia
Allostasis Definition & Areas
- How the body responds to stressors to regain homeostasis
- Areas
- Anterior cingulate cortex: conscious emotions
- Subgenual component of ACC: regulates emotional responses
Parts of brain that generate visceromotor commands to hypothalamus
- Anterior cingulate cortex
- Amygdala
- Anterior insula
Hippocampus
short term memmory
Parahippocampal Gyrus
Encoding & retrieval
Basal Forebrain
- Vental striatopallidal system = appetitive motor system (motivation to work for environmental stim = reward)
- Just inferior to the anterior commissure

Dorsal vs Ventral DA
Dorsal = movement
Ventral = reward
Habenula
- Nucleus of disappointment/negative valence
- Embedded in posterior end of stria medullaris thalami
- Lateral habenula receives inputs (via the stria medullaris thalami) from the ventral pallidum and lateral hypothalamus
- Outputs (via “fasciculus retroflexus”) target the SNc and VTA in the midbrain where habenular inputs ultimately inhibit dopaminergic neurons
- Basically takes away DA by inhibiting the VTA, so you’re not pairing the behavior to reinforcement

Nucleus Accumbens
- Part of the ventral striatopallidal system (VSS) = motivation/reward
- Receives excitatory inputs from amygdala, hippocampus, vmPFC, lateral hypothalamus
- Located in basal forebrain

Anterior Nucleus of Thalamus
- Input
- Hippocampus (via fornix, mammillary bodies)
- Midbrain (acetylcholine)
- Output
- Cortex of cingulate gyrus

Pulvinar
- A thalamic nucleus
- Mostlly located in superior cistern
- Function: integration of stim in different sensory domains
- Inputs: retina, superior colliculus, spinothalamic tract
- Output: where pathway in parietal lobe
- Lesions = visual perception, pain perception, language processing

Lateral Geniculate Nucleus
- Located beneath pulvinar, laterally
- Ending of the optic tract
- Input: contralateral visual field (optic tract)
- Output: primary visual cortex (V1) surrounding calcarine fissure in occipital lobe via optic radiations
Medial geniculate nucleus
- Medial to lateran geniculate nucleus, below pulvinar
- Input: auditory input from inferior colliculus
- Tonotopically organized
- Output: auditory radiations in Heschl’s gyrus of temporal lobe
- Connects via the inferior quadrigeminal brachium
Inferior quadrigeminal brachium
- Connection between medial geniculate body and inferior colliculus (auditory info)
Epithalamus
- Contains
- Pineal body
- Habenula
- Stria medullaris thalami
- Posterior commissure
Retrolenticular Part
- Optic radiation off of posterior limb of internal capsule
- Supplied by M2 of MCA
Sublenticular part
- Auditory radiation off of posterior limb of internal capsule
- Supplied by M2 of MCA
Lentiform nuclei
Putamen + globus pallidus