LA components

Question 1

what two types of anaesthesia can there be? where are they metabolised?

Answer 1

ester (blood) or amide (liver)

Question 2

give an example of some ester LAs

Answer 2

cocaine

benzocaine

procaine

tetracaine

Question 3

give some amide LAs

Answer 3

mepivicaine

bupivicaine

lidocaine

prilocaine

articane

Question 4

give the components of LA and their usages

Answer 4

hydrophobic aromatic region = enter membrane and operate in cell

ester / amide (type of LA)

basic amine side chain (hydrophilic) = so can be water diluted and allow flow in tissue fluid

vasoconstrictor = inhibit natural dilation of local. increases duration of the local.

Question 5

how does the vasoconstrictor in local work?

when should you be wary?

Answer 5

act on receptors on smooth muscle to cause constriction.

act on alpha receptors.

felypressin and optipressin should never be given to a pregnant woman as it can induce labour.