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AU16 Perio > L9 Pathogenesis > Flashcards

L9 Pathogenesis Flashcards

1
Q

Tissue volume ratios

A

JE: 10%
OE: 30%
CT: 60%

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2
Q

Dentogingival plexus venules in health

A

no loops

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3
Q

Reasons for stability of healthy gingiva

A 
Shedding of epithelial cells
Intact epithelial barrier
Positive GCF flow
Complement system
PMNS and macrophages
Antibodies
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4
Q

States of gingivitis/periodontitis

A

Initial lesion: subclinical
Early lesion: clinical state of gingivitis
Established lesion: chronic gingivitis
Advanced lesion: progression to periodontitis

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5
Q

Initial lesion
Days
characteristics

A 
1-4 days
Increase permeability
INcrease PMNS and monocytes
Increase GCF
Decrease collagen
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6
Q

Chemotaxis by PMNS induced by
Host factors
Bacterial factors

A

Host factors: IL-8, C5a

Bacteria molecule: fMetLeuPhe

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7
Q

Early lesion

Days

A

4-7 days
Fibroblasts undergoing cytopathic alterations
Inflammation clinically evident
Collagen destruction
Lymphoid cells immediately subjacent to to JE
Proliferation of basal cells in JE

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8
Q

Established lesion

Cells present

A

Macrophages, Serum proteins PLUS T, B, and Plasma Cells

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9
Q

Established lesion

Characteristics

A

JE converts to PE

Increased proportion of plasma cells

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10
Q

Advanced lesion

Characteristics

A

Conversion from T to B cell predominance

Destruction of CT attachment and apical migration

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11
Q

Effects of diabitetes mellitus

A

Xerostomia
Candida infections
Periodontitis
Periodontal abscesses

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12
Q

Diabetes and periodontitis

A

Periodontitis increases insulin resistance

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13
Q

Effects of diabetes on host response

A 
PMN function and chemotaxis impaired
Advanced Glycation End products 
-make destructive macrophages
-ROE-->cell damage
-Vascular thickening-->O2 diffusion
Decrease fibroblasts and osteoblast synth
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14
Q

Estrogen effects

A

Affects salivary peroxidases
Increase collagen metabolism
Increase vascular response and inflammatories
Increase inflammation and bleeding

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15
Q

Pregnancy
Gingivitis incidence
When is it highest
Microbiota

A 
35-88%
Highest in 2nd and 3rd trimesters
P. intermedia
Napthoquinone supports Pi
Increase spirochetes
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16
Q

pregnancy effects on host

A 
Increase vascular permeability
Increase gingival exudate
Decrease keratinization
DECREASE PMN chemotaxis and phagocytosis
DECREASE antibody and T cell response
17
Q

Perio treatment in pregancy best when

A

2nd trimester

18
Q

Effects of smoking

A 
Lower bleeding on probiing
Decrease leuko in pocket, increase in blood
Decrease blood vesels
Increase keratinization
Lower GCF
Decrease PMN function

AU16 Perio (11 decks)

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