L6

Question 1

Risk factors for periodontitis

Answer 1

Smoking

Diabetes

Question 2

Oral Dysbiosis

Answer 2

Even if a bad bacteria gets into a pocket, often it wont do anything unless it has the other bacteria species it needs

Question 3

P. gingivalis healthy vs disease genotypes

Answer 3

Healthy: I and V fimA
Disease: II and IV fim A

Question 4

Effects of iron on bacteria

Answer 4

Can increase outer membrane protein expression in P gingivalis

Question 5

Steps of gingival health/gingivitis

Answer 5

Reduced Plaque
Reduced Inflammation
Reduced GCF flow, Higher Eh
G(+) facultative anaerobes

Question 6

Pathogenic mechanisms

Answer 6

Adhesins biding to host receptors
Coaggregation
Nutrient utilization
Competitive inhibition

Question 7

Overcoming host defenses

Answer 7

Desquamation of epithelium: invade
Prevent antivody binding: proteases, mimicing
Phagocytic cells

Question 8

Red Group of bacteria plus bad one

Answer 8

P. gingivalis
T. denticola
T. forsythia
A. actinomycetemcomitans

Question 9

Aggregatibacter actinomycetemcomitans
Gram
Motility
Colonies

Answer 9

Gram (-)
Non motile
Star shaped colonies

Question 10

AA serotypes

Answer 10

Based on polysaccharides ons surface
Patients only infected with one serotype
Serotype b most common in USA aggressive periodontitits

Question 11

Evidence at AA for pathogen

Answer 11

Association=bad
Elimination=good
Antibody response
Virulence factors

Question 12

AA virulence factors

Answer 12

Leukotoxin
Fibroblast inhibiting factor
Endotoxin
COllagenase

Question 13

Elimination of AA

Answer 13

Surgical approach required

Question 14

Porphyromonas gingivalis
Gram
Aerobic
Motility

Answer 14

Gram negative
Anaerobic
non-motile

Question 15

P. gingivalis virulence factor

Damaging host tissue and spreading

Answer 15

Cysteine proteinases
-ARG-gingipain
-LYS-gingipain
Important in maturation in surface proteins

Question 16

Evidence against P. gingivalis as pathogen

Answer 16

Seen in health
Not always in disease
Antibody, not cell mediated response
Not numerous subgingivally

Question 17

Virulence factors of P. gingivalis

Colonization and attachment

Answer 17

Fibriae
Hemagglutinins
OMPs
Vesicles

Question 18

Virulence factors of P. gingivalis

Evading host

Answer 18

Ig and complement proteases
LPS
Capsule
Antiphagocytic products

Question 19

Virulence factors of P. gingivalis

multiplying

Answer 19

Proteinases

Hemolysins

Question 20

Tannerella fosythia
Gram
Aerobic
Shape

Answer 20

Gram (-)
Anaerobic
Spindle

Question 21

T. forsythia

requirement for growth

Answer 21

N-acetylmuramic acid

Question 22

T. forsythia

Co-cultivates with

Answer 22

F. nuc

Question 23

Treponema denticola
Grame
Aerboic
Shape

Answer 23

Gram (-)
Anaerobic
Helical

Question 24

T. denticola characteristic

Answer 24

Highly motile (can translocate)

Question 25

Prevotella intermedia/nigrescens
Gram
Aerobic
Shape

Answer 25

gram (-)
Anaerobic
Short round ended rod

Question 26

Prevotella intermedia/nigrescens

Colonies

Answer 26

black pigmented Bacteriodes

Question 27

Prevotella intermedia/nigrescens

Growth in specific chemical

Answer 27

Napthoquinone

Question 28

Associated with puberty/pregnancy gingivitis

Answer 28

P. intermedia/nigrescens (estrogen promotes napthoquinone)

Question 29

Fusobacterium nucleatum
Gram
Aerobic
Shape

Answer 29

Gram (-)
Anaerobic
Spindle shaped rod

Question 30

Fusobacterium nucleatum

Characteristics

Answer 30

Early colonizer in plaque
Bridging organsim
Subgingival

Question 31

T. forsythia cell surface

Answer 31

Serrated S-layer

• Mediates adhesion
• Hemagglutination