L8: Cell Organelles Flashcards
Which disease is caused by the absence of Hex-A?
Tay-Sachs disease
What are the symptoms of Tay-Sachs?
Seizures, muscle rigidity, blindness. Death often before the age of 5
Tay-Sachs is caused by the absence of a single lysosomal enzyme, Hex-A. What does Hex-A break down?
Ganglioside GM2, prevalent in nerve cells
How does Tay-Sachs disease work?
Lack of Hex-A results in a build up of ganglioside GM2 in nerve cells, destroying nerve function
What is Cytoplasm?
Contains cellular components outside the nucleus and within the plasma membrane.
- cytosol
- organelles
Describe the cytoskeleton. What are the 3 main types?
Network of protein filaments throughout the cytoplasm.
- Microfilaments
- Intermediate filaments
- Microtubules
Where would you most likely find ACTIN and MYOSIN?
Microfilaments
Where would you find the microfilaments?
Surrounding the edge of the cell
What are the key functions of the microfilaments?
- Generate movement
- Structural support and shape
- Create microvilli
Which structure is made up of keratin, vimentin, and lamin?
Intermediate filaments
What are the characteristics of the intermediate filaments?
- Very strong
- Found in parts of the cell subject to high stress
- Stabilise the organelles
What structure is formed of Tubulin?
Microtubules
What are the physical features of microtubules?
- Long
- Unbranched
- Hollow
Where do the microtubules form?
Centrosomes
List the functions of the microtubules.
- Structural support and shape
- Movement of organelles during division
- Provide structure for the flagella
What components form a centrosome?
2 centrioles
Where are centrosomes located?
Proximal to the nucleus