L7 Hematopoiesis & Bone Marrow

Question 1

What type of lymphoid organ is bone marrow?

Answer 1

primary

Question 2

Where does the developement of blood cell take place?

Answer 2

bone marrow

Question 3

What are the two types of bone marrow?

Answer 3

yellow marrow and red marrow

Question 4

What are the three parts of red marrow?

Answer 4

stroma
Hematopoietic cords
sinusoidal capillaries

Question 5

Which type of marrow is predominant in newborns?

Answer 5

red marrow

Question 6

Where is red marrow located in adults?

Answer 6

spongy bone and end of long bones

Question 7

What is the most important cell to identify in a bone marrow section image?

Answer 7

megakaryocyte

Question 8

What is the difference b/n bone marrow aspiration and biopsy?

Answer 8

aspiration collects bone marrow into a syringe; biopsy cuts out an intact piece of bone marrow

Question 9

What characterizes aplastic anemia?

Answer 9

hypocellular bone marrow

meaning that the bone marrow is mostly adipose tissue and there is a lack of hematopoietic activity

Question 10

What characterized acute myelogenous leukemia?

Answer 10

hypercellular bone marrow

meaning bone marrow is mostly myoblasts, lack of adipose tissue, and increased blood cell development

Question 11

What are the stages of fetal hematopoiesis before birth?

Answer 11

Stage 1,2, and 3

Question 12

Fetal Hematopoiesis:

What is stage 1? Where does it occur?

Answer 12

formation of RBC blood islands
embryonic yolk sac

Question 13

Fetal Hematopoiesis:

What is stage 2? Where does it occur?

Answer 13

all RBCs and some WBCs are produced
liver

Question 14

Fetal Hematopoiesis:

What is stage 3? Where does it occur?

Answer 14

all RBC and WBCs are produced
bone marrow

Question 15

What cell generates RBCs, WBCs, and platelets in adult hematopoiesis?

Answer 15

myeloid stem cells

Question 16

Myeloid stem cells directly produce which cells?

Answer 16

megakaryoblasts proerythroblasts, and myeloblasts

Question 17

proerythroblasts produce which mature cells?

Answer 17

RBCs

Question 18

myeloblasts produce which mature cells?

Answer 18

Leukocytes WBCs

Question 19

Megakaryoblasts produce which mature cells?

Answer 19

platelets

Question 20

What hormone regulates thrombopoiesis?

Answer 20

thrombopoietin

Question 21

What are the 4 steps of thrombopoiesis?

Answer 21

1: myeloid stem cells
2: megakaryoblast
3: megakaryocyte
4: platelets

Question 22

How long does erythropoiesis take?

Answer 22

7 days

Question 23

What hormone regulates erythropoiesis?

Answer 23

eryhtropoietin

Question 24

In erythropoiesis what happens to cells size as the process progresses?

Answer 24

it decreases

Question 25

What is the largest cells in the erythropoiesis process?

Answer 25

proerythroblast

Question 26

What is the smallest cell in the erythropoiesis process?

Answer 26

erythrocyte

Question 27

Which stage in erythropoiesis does the cell have a nucleoli?

Answer 27

stage 2

Question 28

What is the cell progression in erythropoiesis?

Answer 28

1. myeloid stem cell 2. proerythroblast 3. basophilic erythroblast 4. polychromatophilic erythroblast 5. Normoblast 6. reticulocyte 7. erythrocyte

Question 29

What is the last stage in erythropoiesis where the cell contains a nucleus ?

Answer 29

step 5; as a normocyte

Question 30

What is the largest cell during leukopoiesis?

Answer 30

promyleocyte

Question 31

What are the cell stages of leukopoiesis?

Answer 31

1. myeloid stem cell 2. promyelocyte 3. myelocyte 4. metamyelocyte 5. band cell (only neutrophils) 6. mature granulocytes "My prophyte make me made so I must be neutral somtimes"

Question 32

What granules are produced in leukopoiesis step 3?

Answer 32

primary and secondary granules

Question 33

What color to eosinophils stain?

Answer 33

pink/orange

Question 34

What color to basophils stain?

Answer 34

dark purple

Question 35

What color do neutrophils stain?

Answer 35

purple

Question 36

Which mature granulocytes are multi-lobe?

Answer 36

neutrophils and eosinophils

Question 37

Which cell can leave the blood and migrate into tissue to become macrophages?

Answer 37

monocytes

Question 38

Where are monocytes produced?

Answer 38

bone marrow

Question 39

What happens to b-cells when the migrate into tissues?

Answer 39

the become plasma cells

Question 40

Which cells are the only cells that can recirculate in the blood?

Answer 40

lymphocytes

Question 41

Where are agranulocytes produced?

Answer 41

T-cells --> thymus B-cells --> bone marrow

Question 42

What is the function of the thymus?

Answer 42

to produce t-cells

Question 43

What type of organ is the thymus?

Answer 43

primary lymphoid organ

Question 44

What are the three main parts of the thymus structure?

Answer 44

capsule, cortex, and medulla

Question 45

The darker cortex of the thymus contain which type of cells?

Answer 45

immature t-cells

Question 46

The lighter cortex of the thymus contains which type of cells?

Answer 46

mature t-cells

Question 47

What characteristic cell of the thymus is responsible for development and maturation of t-cells (thrombocytes)?

Answer 47

epithelioreticular cells (nurse cells)

Question 48

Why is it that the thymus lacks b-cell interaction?

Answer 48

bc it lacks lymphatic nodules

Question 49

Which condition is assoc. w lack of nurse cells (epithelioreticular cells)

Answer 49

DiGeorge Syndrome