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Histology > L7 Hematopoiesis & Bone Marrow > Flashcards

L7 Hematopoiesis & Bone Marrow Flashcards

1
Q

What type of lymphoid organ is bone marrow?

A

primary

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2
Q

Where does the developement of blood cell take place?

A

bone marrow

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3
Q

What are the two types of bone marrow?

A

yellow marrow and red marrow

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4
Q

What are the three parts of red marrow?

A

stroma
Hematopoietic cords
sinusoidal capillaries

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5
Q

Which type of marrow is predominant in newborns?

A

red marrow

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6
Q

Where is red marrow located in adults?

A

spongy bone and end of long bones

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7
Q

What is the most important cell to identify in a bone marrow section image?

A

megakaryocyte

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8
Q

What is the difference b/n bone marrow aspiration and biopsy?

A

aspiration collects bone marrow into a syringe; biopsy cuts out an intact piece of bone marrow

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9
Q

What characterizes aplastic anemia?

A

hypocellular bone marrow

meaning that the bone marrow is mostly adipose tissue and there is a lack of hematopoietic activity

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10
Q

What characterized acute myelogenous leukemia?

A

hypercellular bone marrow

meaning bone marrow is mostly myoblasts, lack of adipose tissue, and increased blood cell development

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11
Q

What are the stages of fetal hematopoiesis before birth?

A

Stage 1,2, and 3

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12
Q

Fetal Hematopoiesis:

What is stage 1? Where does it occur?

A

formation of RBC blood islands
embryonic yolk sac

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13
Q

Fetal Hematopoiesis:

What is stage 2? Where does it occur?

A

all RBCs and some WBCs are produced
liver

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14
Q

Fetal Hematopoiesis:

What is stage 3? Where does it occur?

A

all RBC and WBCs are produced
bone marrow

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15
Q

What cell generates RBCs, WBCs, and platelets in adult hematopoiesis?

A

myeloid stem cells

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16
Q

Myeloid stem cells directly produce which cells?

A

megakaryoblasts proerythroblasts, and myeloblasts

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17
Q

proerythroblasts produce which mature cells?

A

RBCs

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18
Q

myeloblasts produce which mature cells?

A

Leukocytes WBCs

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19
Q

Megakaryoblasts produce which mature cells?

A

platelets

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20
Q

What hormone regulates thrombopoiesis?

A

thrombopoietin

21
Q

What are the 4 steps of thrombopoiesis?

A

1: myeloid stem cells
2: megakaryoblast
3: megakaryocyte
4: platelets

22
Q

How long does erythropoiesis take?

A

7 days

23
Q

What hormone regulates erythropoiesis?

A

eryhtropoietin

24
Q

In erythropoiesis what happens to cells size as the process progresses?

A

it decreases

25
Q

What is the largest cells in the erythropoiesis process?

A

proerythroblast

26
Q

What is the smallest cell in the erythropoiesis process?

A

erythrocyte

27
Q

Which stage in erythropoiesis does the cell have a nucleoli?

A

stage 2

28
Q

What is the cell progression in erythropoiesis?

A
  1. myeloid stem cell
  2. proerythroblast
  3. basophilic erythroblast
  4. polychromatophilic erythroblast
  5. Normoblast
  6. reticulocyte
  7. erythrocyte
29
Q

What is the last stage in erythropoiesis where the cell contains a nucleus ?

A

step 5; as a normocyte

30
Q

What is the largest cell during leukopoiesis?

A

promyleocyte

31
Q

What are the cell stages of leukopoiesis?

A
  1. myeloid stem cell
  2. promyelocyte
  3. myelocyte
  4. metamyelocyte
  5. band cell (only neutrophils)
  6. mature granulocytes

“My prophyte make me made so I must be neutral somtimes”

32
Q

What granules are produced in leukopoiesis step 3?

A

primary and secondary granules

33
Q

What color to eosinophils stain?

A

pink/orange

34
Q

What color to basophils stain?

A

dark purple

35
Q

What color do neutrophils stain?

A

purple

36
Q

Which mature granulocytes are multi-lobe?

A

neutrophils and eosinophils

37
Q

Which cell can leave the blood and migrate into tissue to become macrophages?

A

monocytes

38
Q

Where are monocytes produced?

A

bone marrow

39
Q

What happens to b-cells when the migrate into tissues?

A

the become plasma cells

40
Q

Which cells are the only cells that can recirculate in the blood?

A

lymphocytes

41
Q

Where are agranulocytes produced?

A

T-cells –> thymus
B-cells –> bone marrow

42
Q

What is the function of the thymus?

A

to produce t-cells

43
Q

What type of organ is the thymus?

A

primary lymphoid organ

44
Q

What are the three main parts of the thymus structure?

A

capsule, cortex, and medulla

45
Q

The darker cortex of the thymus contain which type of cells?

A

immature t-cells

46
Q

The lighter cortex of the thymus contains which type of cells?

A

mature t-cells

47
Q

What characteristic cell of the thymus is responsible for development and maturation of t-cells (thrombocytes)?

A

epithelioreticular cells (nurse cells)

48
Q

Why is it that the thymus lacks b-cell interaction?

A

bc it lacks lymphatic nodules

49
Q

Which condition is assoc. w lack of nurse cells (epithelioreticular cells)

A

DiGeorge Syndrome

Histology (6 decks)

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