L7 Flashcards
involves the collection of all the components necessary for the formation of the mature virion at a particular site in the cell.
assembly process
is the stage of the replication cycle at which the virus becomes infectious.
Maturation
are frequently involved in maturation, although cellular enzymes or a mixture of virus and cellular enzymes are used in some cases.
Virus-encoded proteases
Example of release by budding
Influenza A
Example of release by lysis
Smallpox
is a member of the genus Lentivirus, part of the family Retroviridae.
human immunodeficiency viruses (HIV)
are single-stranded, positive-sense, enveloped RNA viruses.
Lentiviruses
HIV cause?
acquired immunodeficiency syndrome (AIDS).
Contain 3 gens : gag, pol, env and are flanked by long terminal repeats
All retroviral genomes
Encodes 3 main structural protein MA, CA, NC
gag sequence
Encoded protease (PR) responsible for cleaving Gag and Gag-Pol during particles assembly , budding , maturation
Pro sequence
Encodes the enzymes RT, IN
Pol sequence
Responsible for integrating the proviral DNA into tho host cell genome
IN enzymes on pol sequence
integrated HIV DNA
provirus.