L6 - Proteins Flashcards
1
Q
What bond joins Amino Acids?
A
Peptide bonds (condensation)
2
Q
Which direction are proteins notated?
A
N to C terminus
3
Q
Is there free rotation in a peptide bond?
A
No, they are partial double bonds so rigid and planar
4
Q
Which bonds can Proteins rotate about?
A
Alpha carbon - Carbon
Nitrogen - Alpha carbon
5
Q
Psi angle
A
Alpha Carbon - Carbon
6
Q
Phi angle
A
Nitrogen - Alpha carbon
7
Q
Why are most Psi and Phi angles impossible?
A
Steric collisions
8
Q
Steric Collisions
A
Collisions between side chains of amino acids
9
Q
What is the main driving force for protein folding?
A
Energetically stable strucutres
10
Q
How do water soluble proteins fold?
A
Hydrophobic side chains packed in interior forming a core
11
Q
Why must chains form hydrogen bonds
A
To neutralize the hydrophilic polar groups in the main chain
N-H and C=O
