Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

RCS > (L6, L8) Adrenergic Drugs > Flashcards

(L6, L8) Adrenergic Drugs Flashcards

1
Q

epinephrine uses

A
  • anaphylactic shock
  • acute asthmatic atacks
  • cardiac arrest
  • local anesthetics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

explain the differences in function of varying epinephrine doses

A

Low- mainly β agonist

High (therapeutic doses)- α1 response predominates and β1 effects in heart opposed by baroreceptor reflex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

norepinephrine mainly effects (1) receptors and is used for (2)

A

1- α1, β1 agonist

2- shock (inc vascular resistance –> inc BP)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

dopamine mainly effects (1) receptors and is used for (2)

A

1- D1 > β1 > α1 agonist

2- severe CHF, cardiogenic / septic shock (intermediate to high doses)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Isoproterenol is a (1) type adrenergic agent and is used for (2)

A

1- direct acting non-selective β agonist

2- emergencies: stimulates HR in patients with bradycardia or heart block

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

_____ is used for emergencies to stimulate HR in patients with bradycardia or heart block

A

isoproternol (non-selective β agonist)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Dobutamine is a (1) type adrenergic agent and is used for (2)

A

1- direct acting selective β1 agonist

2- acute HF, cardiogenic shock, nonexercise stress tests

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

______ is used for acute heart failure, cardiogenic shock, and nonexercise stress tests

A

dobutamine (selective β1 agonist)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Albuterol is a (1) type adrenergic agent and is used for (2)

A

1- direct acting selective β2 agonist, short-acting

2- acute asthma Sxs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

(1) is used for acute asthma symptoms

(2) is used for long-term asthma management

A

1- albuterol (selective β2 agonist, short-acting)

2- salmeterol, formoterol (selective β2 agonist, long-acting)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Salmeterol and Formoterol are (1) type adrenergic agents and are used for (2)

A

1- direct acting selective β2 agonist, long-acting

2- asthma Sxs (slow onset and long duration of action - albuterol is opposite)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Phenylephrine is a (1) type adrenergic agent and is used for (2)

A

1- direct acting selective α1 agonists
2- nasal congestion, mydriasis, inc BP in hypotension due to septic shock or anesthesia or to terminate episodes of supraventricular tachycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

_______ is used for nasal congestion, mydriasis, to increase BP in hypotension due to septic shock or anesthesia, or to increase BP / terminate episodes of supraventricular tachycardia

A

phenylephrine (selective α1 agonists)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Clonidine is a (1) type adrenergic agent and is used for (2)

A

1- direct acting selective α2 partial agonists (antagonist effects)
2- HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Methyldopa is a (1) type adrenergic agent and is used for (2)

A

1- direct acting selective α2 agonists

2- HTN in pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

______ is used to treat HTN in pregnancy

A

methyldopa (selective α2 agonists)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Brimonidine is a (1) type adrenergic agent and is used for (2)

A

1- direct acting selective α2 agonists

2- glaucoma (reduces aqueous humor –> lowers intraocular pressure)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Amphetamine is a (1) type adrenergic agent with a (2) MOA, and is used for (3)

A

1- indirect acting agonist, releasing agent
2- inc NE release (inc BP - α agonist, heart effects - β agonist)
3- ADHD, narcolepsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Methylphenydate is a (1) type adrenergic agent with a (2) MOA, and is used for (3)

A

1- indirect acting agonist, releasing agent
inc NE release (inc BP - α agonist, heart effects - β agonist)
3- ADHD in children

20
Q

(1) is used for ADHD, (2) is specifically for children

A

1- amphetamine (inc NE release from SNS), atomoxetine (selective inhibitor of NE reuptake transporter)
2- methylphenydate (inc NE release from SNS)

21
Q

_____ is used for narcolepsy

A
  • amphetamine (inc NE release)

- modafinil (inhibits NE/DA reuptake)

22
Q

Tyramine is a (1) type adrenergic agent with a (2) MOA, and is used for (3)

A

1- indirect acting agonist, releasing agent
2- inc NE release from SNS in people on MAOIs
3- N/A

23
Q

Cocaine is a (1) type adrenergic agent with a (2) MOA

A

1- indirect acting agonist, uptake inhibitor

2- monoamine reuptake inhibitor

24
Q

Atomoxetine is a (1) type adrenergic agent with a (2) MOA, and is used for (3)

A

1- indirect acting agonist, reuptake inhibitor
2- selective inhibitor of NE reuptake transporter
3- ADHD

25
Q

Modafinil is a (1) type adrenergic agent with a (2) MOA, and is used for (3)

A

1- indirect acting agonist, reuptake inhibitor
2- (somewhat unknown psychostimulant) inhibits DA/NE reuptake transporter
3- narcolepsy

26
Q

Ephedrine is a (1) type adrenergic agent with a (2) MOA, and is used for (3)

A

1- mixed acting agonist
2- induces NE release (long duration, penetrates CNS)
3- pressor agent (during spinal anesthesia), myasthenia gravis Tx

27
Q

_______ is a pressor agent during spinal anesthesia and is used to treat myasthenia gravis

A

ephedrine (mixed acting agonist, inc NE release)

28
Q

Pseudoephedrine is a (1) type adrenergic agent with a (2) MOA, and is used for (3)

A

1- mixed acting agonist
2- induces NE release
3- decongestant

29
Q

_____ is used as a nasal decongestant

A
  • phenylephrine (selective α1 agonist)

- pseudoephedrine (inc NE release)

30
Q

Phenoxybenzamine is a (1) type adrenergic agent and is used for (2)

A

1- irreversible non-selective α antagonist

2- pheochromocytoma (prior to surgery)

31
Q

Phenotolamine is a (1) type adrenergic agent and is used for (2)

A

1- reversible non-selective α antagonist

2- prevent HTN crisis in pheochromocytoma surgery and for its Dx + prevents dermal necrosis after NE extravasation

32
Q

(1) is used prior to pheochromocytoma surgery

(2) is used during pheochromocytoma surgery

A

1- phenoxybenzamine (irreversible non-selective α antagonist)
2- phenotolamine (reversible non-selective α antagonist - prevent HTN crisis)

33
Q

Prazosin is a (1) type adrenergic agent and is used for (2)

A

1- selective α1 antagonist (prototype)

2- HTN (2nd/3rd line), BPH

34
Q

Terazosin and Doxazosin are a (1) type adrenergic agents and are used for (2)

A

1- selective α1 antagonist (longer half-life than prazosin)

2- HTN (2nd/3rd line), BPH

35
Q

Tamsulosin is a (1) type adrenergic agent and is used for (2)

A

1- selective α-1a antagonist

2- BPH

36
Q

selective α1 antagonists are used to treat…..

A

(prazosin, terazosin, doxazosin, tamsulosin)

  • HTN (not tamsulosin, selective α-1a antagonist)
  • BPH (all)
37
Q

discuss the difference is using a non-selective β antagonist versus using a selective β1 antagonist

A

non-selective β (propanolol, nadolol, timolol): HTN in non-impaired pulmonary and non-diabetic patients

selective β (atenolol, metoprolol): HTN in COPD, asthma, DM patients

38
Q

Propanolol is a (1) type adrenergic agent and is used for (2)

A

1- non-selective β antagonist (prototype)

2- HTN

39
Q

Nadolol and Timolol are (1) type adrenergic agents and are used for (2)

A

1- non-selective β antagonist

2- HTN

40
Q

Atenolol and Metoprolol are (1) type adrenergic agents and are used for (2)

A

1- selective β1 antagonist

2- HTN for COPD, asthma, DM patients

41
Q

Esmolol is a (1) type adrenergic agent and is used for (2)

A

1- selective β1 antagonist (ultra-short acting, IV for 10 min half-life)
2- AFib, atrial flutter (controls ventricular rate)

42
Q

Labetalol and Carvedilol are (1) type adrenergic agents and are used for (2)

A

1- competitive α1, β antagonists (more potent for β receptors)
2- HTN [CHF for carvedilol]

43
Q

Pindolol is a (1) type adrenergic agent and is used for (2)

A

1- partial β agonist

2- people with diminished cardiac reserve or that have propensity to bradycardia

44
Q

______ is used in people with diminished cardiac reserve or that have propensity to bradycardia

A

pindolol (partial β agonists)

45
Q

(1) and (2) inhibit NE storage via (3) and (4) mechaisms respectively. (1) is used for (5) and (2) is used for (6).

A

1/3- Tetrabenazine: reversible inhibitor of VMAT
5- chorea in Huntington’s disease

2/4- Reserpine: irreversible inhibitor of VMAT
6- previously HTN

46
Q

(1) inhibits NE synthesis via a (2) mechanism and is used for (3)

A

1- α-methyltyrosine
2- competitive inhibitor for Tyrosine Hydroxylase
3- manages malignant pheochromocytoma or in its preoperative resection

RCS (29 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions