L28- CVS Pathology VI Flashcards
pericardial diseases usually result from (1) or (2)
1- effusions and hemopericardium
2- inflammations (pericarditis)
-mostly secondary to cardiac or systemic diseases
(1) is the distension of the pericardial sac due to fluid accumulation. The fluid can be (2), (3), (4), or (5).
1- pericardial effusion and hemopericardium
2- serous (CHF, hypoalbuminemia)
3- serosanguineous- some blood (trauma, malignanvy)
4- chylous- lymph, fatty (mediastinal lymphatic obstruction)
5- blood = hemopericardium (cardiac tamponade via aortic dissection, MI, penetrating trauma)
Pericardial effusion effects are dependent on (1). The pericardium is able to hold up to (2) amount of fluid. Rapid accumulation of (3) amount of fluid can cause (4).
1- speed / rate of accumulation
2- 1L (pericardium is able to stretch if slow accumulation, normally holds 30-50 mL)
3- 250mL
4- tamponade
(Primary/Secondary) pericarditis is more common. Primary pericarditis is caused by (2). Secondary pericarditis is caused by (3).
1- secondary (primary is uncommon)
2- usually infectious, mostly viral
3- uremia** (most common, CKD), MI, cardiac surgery, radiation induced, rheumatic fever, SLE, malignancies
list the 4 types of pericarditis (include common causes)
- Fibrinous: ‘bread and butter’, irregular and shaggy; seen in rheumatic disease, uremia, post-MI, post-viral
- Fibrous and Hemorrhagic: malignancies
- Fibrinopurulent / suppurative: bacterial pericarditis
- Caseous: Tb
list the clinical features of acute pericarditis (minus cardiac tamponade signs)
- atypical chest pain: no relation to exertion, worsens with reclining, relieved by leaning forward
- high-pitched friction rub
list the signs of Cardiac Tamponade
- faint distant (muffled) heart sounds
- distended neck veins
- declining CO
- shock
what are the 3 outcomes of pericarditis
1) resolution, no clinical sequalae
2) immeadiate hemodynamic complications with large enough effusion
3) progress to chronic fibrosing: following caseous (Tb) or suppurative (bacterial) –> chronic constrictive pericarditis
Chronic percarditis produces a combination of (1) and (2) signs, similar to (3).
It usually has (4) present within pericardial space, and in severe/extreme cases (5) can be evident.
1- R sided venous distension
2- low CO
3- restrictive CM
4- delicate adhesions to dense, fibrotic scars that obliterate pericardial space
5- heart is completely encased with dense scar tissue, not allowing heart expansion –> constrictive pericarditis
define constrictive pericarditis
- a result of chronic percarditis
- pericardium is entirely dense scar tissue, encasing the heart
- this doesn’t allow the heart to expand
what are the layers of arteries
Intima- endothelial cells
Media- smooth muscle cells
Adventitia- CT
what are the 2 principle mechanisms of blood vessel disease
-Narrowing or Complete Obstruction of lumen: i) progressive due to atherosclerosis; ii) suddenly due to thrombosis
what are the ‘other’ diseases of blood vessels
- HTN
- inflammation disorders / vasculitis
- congentital malformation
- neoplasms
define arteriosclerosis
- hardening of arteries
- generic term for arterial wall thickening and loss of elasticity
list the types of arteriosclerosis
1) arteriolosclerosis: small arteries, arterioles; hyperplastic or hyaline
2) Monckeberg medial sclerosis: tunica media calicification in muscular arteries (never encroach vessel lumen, age 50 yrs and not clinically significant)
3) atherosclerosis
list the Non-Modifiable Major risk factors for atherosclerosis
- age
- gender
- genetic predisposition
list the Modifiable Major risk factors for atherosclerosis
- hyperlipidemia
- HTN
- DM
- cigarette smoking
list the additional / uncertain risk factors for atherosclerosis (note- exhaustive list)
- hyperhomocystinemia
- lipoprotein-a
- fibrinolysis inhibitors
- elevated PA-1 inhibitors
- CRP
- lack of exercise (sedentary life-style)
- post-menopausal estrogen deficienct
- ‘type A’ personality
- obesity
- unsaturated fat intake
- high carb diet
- chlamydia pneumoniae
how is age and atherosclerosis related
- risk starts in childhood and progresses / increases with age
- 40-60 y/o have 5x inc incidence in MIs
define atherosclerosis
(atheros in greek = soft gruel or porridge like)
- hardening of arteries
- chronic inflammatory disorder of intima of large arteries
- characterized by formation of fibro-fatty plaques, atheroma
Atherosclerosis is more common in (male/females). Therefore it is uncommon in (2) people and those who are on (3).
1- males
2- premenopausal
3- postmenopausal women on hormone replacement therapy
how do genetics affect atherosclerosis
- familial clustering (aggregation of trait, behaviors, disorders in a family) of ‘other risk factors’
- familial hypercholesterolemia
In the relationship between hyperlipidemia and atherosclerosis, (1) is most important. Therefore it has a direct correlation to (2) and inverse relationship to (3). If in combination with (4), premature and severe atherosclerosis will result.
1- elevated cholesterol (hypercholesterolemia)
2- LDL levels
3- HDL levels
4- DM, nephrotic syndrome, hypothyroidism
HTN is most important in terms of causing atherosclerosis after (1).
- there is a 5x more risk of developing IHD with (2) BP compared to (3) BP
- antihypertensives help reduce the risk of (4)
1- 45 y/o
2- 169/95
3- 140/90
4- (atheroclerosis causing…) stroke, IHD