L3.9 Molecular Targets of Drug Action

Question 1

What are the types of receptors, their time scale and an example of each?

Answer 1

GPCR- seconds, ACh receptor
Ligand gated ion channel- milliseconds, nicotinic
Kinase linked receptor- hours, cytokine receptor
Nuclear receptors- hours, oestrogen receptor

Question 2

What are NM and NN?

Answer 2

Nm is the nicotinic receptor in skeletal muscle and NN is the nicotinic receptor in the CNS

Question 3

Where do alpha and beta adrenoceptors bind?

Answer 3

α1-adrenoceptors on most blood vessels
α2-adrenoceptors on some nerves
β1-adrenoceptors predominate in the heart
β2-adrenoceptors on bronchi and some blood vessels