L3.5 Bacterial Pathogenesis

Question 1

What are Kochs postulates?

Answer 1

• Organism found in all patients with disease
• Distribution corresponds to lesions
• Cultivate outside host for several generations
• Reproduce the disease in other species
• Demonstrate a specific immune response

Question 2

What bacteria have LPS?

Answer 2

Gram negative

Question 3

Whats the difference between commensals and pathogens?

Answer 3

Commensals protect the body and pathogens endanger the body.

Commensals dont adhere tightly to cells and are usually in the mucous and pathogens adhere tightly and specifically

Question 4

What is the difference between active and passive immunity?

Answer 4

Passive immunity is when the antibodies are given directly to the individual and active is when a vaccine is administered so that the body will make antibodies

Question 5

What are the features of K88 and what did K88 and the vaccine do in pigs?

Answer 5

K88: protein, fimbrial antigen

If piglets were given K88 they could be immune to tetanus

Question 6

How does tetanus occur?

Answer 6

Caused by clostridium tetani because spores get into umbilical stump. Spores get into dead tissue of umbilical cord, produce toxins. Vaccine for tetanus is DPT - immunise mother - IgG antibodies cross placenta and baby is immune to clostridium tetani.