L31 Protein & Alcohol Metabolism Flashcards

1
Q

Amino acids are not stored by the body, thus must be topped up via…

A

Diet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Proteins are broken down by…

A

Proteases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Remaining tripeptides and dipeptides are broken down into amino acids by…

A

Peptidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

During long term starvation, the body acquires amino acids from:

a) breaking down structural and functional proteins
b) metabolic reactions
c) storage molecules
d) all of the above

A

a) breaking down structural and functional proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The most common cause of death in chronic malnutrition is from infections. In terms of amino acids explain why…

A

In the absence of amino acids, the body is unable to produce antibodies. Without antibodies the immune system is compromised and highly susceptible to infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The alpha amino group of amino acids is toxic. It is recycled via the…

A

Urea cycle, in which it is converted to NH4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Transaminases are a key enzyme in…

A

Amino acid metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Amino acids can be used as an energy source. For example glutamate in converted into alpha ketoglutarate via ? Which is used in the ? To generate energy.

A

Glutamate dehydrogenase

Used to Citric acid cycle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

All amino acids are converted through 7 intermediates which are either…

A

Glucogenic or ketogenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The body can build new types of amino acids by adding amino groups using…

A

Amino acyl transferase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Alcohol binds to…

A

GABA receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Symptoms of alcohol toxicity range from…

A

Relaxation and mild euphoria to stupor and death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Differences in alcohol metabolism between men and women can be explained by differences in…

A

Weight and body composition.

Lower weight = lower blood volume

Higher body fat - fat doesn’t absorb alcohol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The two key enzymes involved in alcohol metabolism are…

A

Alcohol dehydrogenase

Aldehyde dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Ethanol is converted to acetaldehyde by…

A

Alcohol dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Acetaldehyde is toxic and responsible for the symptoms of…

A

Hangover

17
Q

Acetaldehyde is converted to…

A

Acetic acid by aldehyde dehydrogenase

18
Q

Acetic acid can cause damage to the…

A

Liver

19
Q

Excessive alcohol consumption depletes…

A

NAD+

20
Q

Depleted NAD+ resulting from excessive alcohol consumption tricks the body into thinking there is plenty of energy. Therefore (4)…

A

Glycolysis stops
CAC stops
Gluconeogenesis stops

Leading to hypoglycaemia

21
Q

Acetic acid is converted to acetyl CoA which is used in the citric acid cycle. This leads to…

A

Lipogenesis

22
Q

Lipogenesis due to excessive alcohol consumption can lead to…

A

Steatosis aka fatty liver disease

23
Q

In fatty liver disease there are fewer…

A

Hepatocytes and more adipose cells

24
Q

Alcohol intolerance affects the enzyme…

A

Acetaldehyde dehydrogenase

25
Q

Acetylaldehyde dehydrogenase is targeted by drugs that treat…

A

Alcoholism

Inhibiting the enzyme mimics the unpleasant symptoms of alcohol intolerance, thus discouraging alcohol consumption