L3: oral histology Flashcards
what are the 3 layers of epithelium in non keratinized oral mucosa
outermost to innermost:
superficial
intermediate layer
basal layer
what are the 4 layers of epithelium in keratinized mucosa
outermost to innermost:
corneal layer (stratum corneum)
granular layer (stratum granulosum)
spinous layer (stratum spinosum)
basal layer (stratum basale)
what is the difference between ortho and para keratinized epithelium
para keratinized got flattened cell nuclei
ortho dont have
what are rete ridges
are epithelial projections into lamina propria
2 kinds of lamina propria
papillary, reticular
what are papilla in the lamina propria
connective tissue projections into epithelium
like interdigitate with rete ridges
defn of hyperkeratosis
thickening of stratum corneum
defn of epithelial hyperplasia aka acanthosis
characterized by increased cell numbers, which usually results in increased thickness of the squamous epithelium
when there is an increase in spinous layer cells, it is called
acanthosis
what is epithelial atrophy
thinning of epithelium associated with decrease in number of epithelial cells
what can counting mitotic figures tell a pathologist
can help to tell benign from malignant or a change towards malignancy
what are mitotic figures
microscopic appearance of a cell undergoing mitosis
instead of a nucleus, chromosomes are visible as tangled, dark staining threads
normal mitosis always happens in which layer in epithelium
basal
in epithelial dysplasia, what happens to nucleus
nuclear size increases leading to increased N:C
what does hyperchromatic nuclei mean and what is it indicative of
dark, strongly stained nucleus
(indicative of proliferative status)
compared to the cells in other layers, basal cells have what kind of nuclei and cytoplasm. as it moved up the layers, what happens?
- basal cells have bigger, darker nuclei and smaller cytoplasm
- as it moves up, nucleus becomes smaller, cytoplasm becomes bigger
- cell flattens out
___ hold keratinocytes together
desmosomes
what does endophytic vs exophytic mean
- endophytic = lesion that appears to grow inwards into underlying tissues (invasive properties, usually more dangerous)
- exophytic: lesion that appears to grow outwards from mucosa
what are the 7 stages of tooth development
1) initiation
2) thickening of dental epithelium
3) bud stage
4) cap stage
5) early bell stage
6) late bell stage
7) root formation stage
in the bud stage, the _____ resembles a small bud
enamel organ