L3 Hemostasis II

Question 1

Disorders of primary hemostasis

Answer 1

Mucocutaneous bleeding
Prolonged bleeding
Decreased platelet count

Question 2

Disorders of secondary hemostasis

Answer 2

soft tissue bleeding
Prolonged
Prothrombin T, Partial Thromboplatstin T, Thrombin time

Question 3

Factor VIII Complex

Components

Answer 3

vWF (platelets and endothelial cells)
Factor VIII (Liver)

Question 4

Von Willebrand disease
Type of disease
I, II, III

Answer 4

Autosomal dominant
I:Decreased vWF
II: Abnormal vWF
III: No vWF

Question 5

von Willebrand disease

Treatment

Answer 5

Mild: desmopressin (releases vWF from endothelial)
Severe: VIII w/ vWF and cryoprecipitate

Question 6

Hemophilia A
Type of disorder
What is it

Answer 6

X linked recessive
Decreased VIII production
Soft tissue bleeding

Question 7

Hemophilia A Lab findings

Answer 7

Normal bleeding time
Prolonged PTT
Decreased VIII
normal vWF
Normal IX

Question 8

Hemophilia B
Type of disorder
What is it

Answer 8

X linked recessive

Decreased IX production

Question 9

Thrombocytopenia
Count
Symptoms

Answer 9

<100,000/uL
Spontaneous bleeding at 20,000
Petechial hemorrhages in skin and mucous membranes

Question 10

Immune Thrombyctopenic Purpura

Acute vs chronic

Answer 10

Immne mediated distruction of platelets
Acute: children, severe,2-6 weeks, boys and girls
Chronic: adults, mild, females

Question 11

Immune thrombocytopenic purpura treatment

Answer 11

Corticosteroids
IV immunoglobulin
Splenectomy

Question 12

Thrombotic Thrombocytopenic Purpura

What is it

Answer 12

Intravascular platelet activation w/
Formation of platelet rich microthrombi throughout circulation
Accumulation of large vWF

Question 13

Thrombotic Thrombocytopenic Purpura

Cause

Answer 13

Deficiency of metalloproteinase ADAMTS 13

usually degrades high MW vWF

Question 14

Disseminated intravascular coagulation

Cause

Answer 14

uncontrolled activation of hemostatic system

bleeding and microvascular thrombi