L3- Antidepressants (NDRIs, NASSAs)

Question 1

list the NDRIs

Answer 1

(NE and dopa reuptake inhibitors)

Bupropion

Question 2

NDRI MOA

Answer 2

(bupropion)

inhibits NET, DAT

Question 3

what is a key AE avoided with NDRIs

Answer 3

(bupropion)

no sexual dysfunction- no serotonergic activity

Question 4

bupropion overdose may lead to…..

Answer 4

seizures

Question 5

list the NASSAs

Answer 5

(noradrenergic and specific serotonergic antidepressants)

Mirtazapine

Question 6

NASSA MOA

Answer 6

(mirtazapine)

• presynaptic α2 receptor antagonist –> inc NE, 5-HT release
• 5-HT2/5-HT3 receptor antagonist
• H1R antagonist –> sedation, weight gain

Question 7

possible use besides depression for mirtazapine

Answer 7

for insomnia or agitation- due to H1R antagonist activity