L20

Question 1

Hubel and Wiesel

Answer 1

Ocular dominance columns organised at birth; development of ODCs requires activity (non-existent if raised in complete darkness)-> thus activity required for synaptic connectivity but not for axons finding 4C chemospecifically
Competition also influences ODCs (dif lenses over dif eyes)
[first weeks]

Question 2

Knudsen and Burrow

Answer 2

(Audition) Prism to misalign sight and hearing by 23 degrees, after 6-8 weeks owl compensates
[<200 days old]

Question 3

BDNF and endocannibinoids cause…

Answer 3

…precocious onset of critical period (CLOCK (TF)-> delayed)

Question 4

OTX2 (TF), Perineural nets cause…

Answer 4

…reactivation of critical period

Question 5

Ethosuximide in absence seizure rat model:

Answer 5

Given in critical period, rats show no seizure onset after 5 months (normal seizure onset)

Question 6

Para^bss seizure mt fly treated with halorhodopsin…

Answer 6

…no seizures

[nb optogenetics]