L2 - Introduction into medicinal products Flashcards
1
Q
pharmaceutics
A
- process of turning a new chemical entity (NCE) into a medication to be used safely and effectively by patients
- aka science of dosage form design
2
Q
for pharmaceutics we need an understnaqding of:
A
- basic physical chemistry
- necessary for the effective design of dosage forms
- relevant body systems
- how drugs arrive there following administration
- dsign and formulation of medicines
- dosage from desing
- manufacture
- avoidance and elimination of microorganisms in medicine
- product performance testing
3
Q
medicines
A
- drug delivery system
- administartion of drug(s) into body in a safe, efficient, accurate, reproducible, and convenient way
4
Q
when do medicines = drugs
A
- when there are no ‘excipients’ present
5
Q
excipient
A
- substance formulated alonside the active ingredient of a medication
- many purposes, e.g.
- stability
- bulking agents
- theraputic enhancement etc
6
Q
major factors that impact dosage from design
A
- physiochemical properties of the drug
- e.g. pKa
- biopharmaceutical considerations
- e.g. how adminsstration route of dosage affects rate and extent of drug absorbtion in the body
- therapeutic considerations
- e.g. patient popuilation, disease state
7
Q
suspension
A
- medicine mixed with a liquid, usually water, in which it can not dissolve and therefore remains intact in the form of small particles
8
Q
topical
A
- applied directly to part of the body
9
Q
transdermal
A
- route of administration wherein active ingredients are delivered across the skin for systematic distribution
10
Q
buccal
A
- relating to mouth
11
Q
Variation of onset of action for different dosage forms:
seconds
A
intravenous injection
12
Q
Variation of onset of action for different dosage forms:
minutes
A
- intramascular and subcutaneous injection
- buccal tablets
- aerosols
- gases
13
Q
Variation of onset of action for different dosage forms:
minutes to hours
A
- solutions
- suspensions
- powders
- granules
- capsules
- tablets
14
Q
Variation of onset of action for different dosage forms:
several hours
A
- enteric coated formulations
15
Q
Variation of onset of action for different dosage forms:
days to weeks
A
- implants
- depot injections
