L2: Homeostasis-maintaining physiological variables Flashcards

- Explain the underlying principles of physiological homeostasis, including the importance of negative feedback - Describe the role of the autonomic nervous system in physiological control - Describe the role of hormonal systems in physiological control - Describe the role of paracrine homeostatic signalling in physiological control - Describe feed-forward and positive feedback control mechanisms

1
Q

What is physiological variable?

A

A measure of a bodily condition or bodily function

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2
Q

What is homeostasis?

A

The changing maintenance of physiological variables within a predictable range

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3
Q

What is negative feedback?

A

Change is sensed, response is initiated to reverse that change

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4
Q

Why is negative feedback important?

A

Control the body’s homeostasis

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5
Q

Why do we need homeostasis? Short term/long term effect?

A

Short term- Immediate survival
Long time- health & well-being

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6
Q

2 examples of physiological variables

A

Blood glucose concentration & blood pressure

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7
Q

What does positive feedback mean?

A

Change in a variable triggers a response to cause further change- amplified

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7
Q

What does a inter-dependent variable mean?

A

Variable that is closely connected & influenced by other variables within a system

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7
Q

What does feed-forward mean?

A

Anticipation of a change brings response to that change before it can be detected by negative feedback sensors

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7
Q

What does osmolality mean?

A

Concentration of particles dissolved in a fluid

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8
Q

Where are the neuronal integrating centres?

A

Midbrain or brain stem

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9
Q

Which nervous systems are there communication with effectors?

A

Sympathetic & parasympathetic nervous systems

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10
Q

What is fine-tuning?

A

Makes very small changes to something in order for it to work as well as possible

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11
Q

What are the 3 classes of hormones?

A
  1. Tyrosine derivatives
  2. Peptides, polypeptides, glycopeptides
  3. Steroids
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12
Q

Features of steroid hormones

A

Insoluble in water

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13
Q

What is the receptor location of steroids?

A

Intracellular: cytoplasm or nucleus

14
Q

What is the receptor location of thyroid hormones?

A

Intracellular: cytoplasm or nucleus

15
Q

What is the receptor location of peptides, glycoprotein?

A

Cell surface: plasma membrane

16
Q

What is the mechanism of action of steroids & thyroid hormones?

A

Alter gene transcription slowly

17
Q

What is the mechanism of action of peptides, glycoproteins?

A

Second messengers to change enzyme activity rapidly

18
Q

What happens in the efferent pathway in the paracrine homeostatic control?

A

Involves secretion of diffusible substances from 1 group of cells to act on another group of cells nearby

19
Q

What type of cells detect INCREASE in blood glucose concentration?

A

Beta cells

20
Q

What type of cells detect a DECREASE in blood glucose concentration?

A

Alpha cells