L2 - Cartilage Histology - Articulate H Flashcards

1
Q

Connective tissues are made up of what two general things? Which of the two is the major component?

A
  1. Cells
  2. Extracellular matrix
    - ECM = major component
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2
Q

Extracellular matrix is composed of what two things that are secreted from the cells?

A
  1. Protein fibers

2. Ground substance

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3
Q

What 3 things make up protein fibers?

A
  1. Collagen fibers
  2. Reticular fibers
  3. Elastic fibers
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4
Q

What 3 things make up the unstructured hydrophilic ground substance?

A
  1. Glycosaminoglycans (GAGs)
  2. Proteoglycans
  3. Multiadhesive glycoproteins
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5
Q

What tissue gives rise to connective tissues? What is this tissues made of?

A
  1. Mesenchyme

2. Mesenchymal stem cells

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6
Q

What type of cell can give rise to endothelium, lipoblasts, fibroblasts, hematopoietic stem cells, mesothelium, osteoblasts, and chondroblasts?

A

Mesenchymal stem cells

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7
Q

What two cells are associated with cartilage and what are their roles?

A

Chondroblasts - Secrete ECM Chondrocytes -Secrete and maintain ECM

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8
Q
  1. What percentage of cartilage is ECM?

2. What is the ECM rich in? 3. What is the function?

A
  1. 95% volume
  2. Rich in GAG’s and proteoglycans
  3. Resilient to mechanical forces
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9
Q

What is the dense connective tissue that covers most cartilage?

A

Perichondrium

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10
Q

Cartilage has or doesn’t have blood vessels?

A

Doesn’t

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11
Q

_____ growth - by addition of new ECM to the existing surface - new chondroblasts

A

Appositional growth

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12
Q

_____ growth - by internal expansion; proliferation of chondrocytes and formation of isogeneous groups

A

Interstitial growth

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13
Q

What are the 3 types of cartilage?

A
  1. Hyaline cartilage
  2. Elastic cartilage
  3. Fibrocartilage
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14
Q

The most common type of cartilage in the human body is?

A

Hyaline cartilage

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15
Q

_____ cartilage’s ECM is largely made of water; it is found in the nose, larynx, and fetal bone models; it has perichondrium present; and appears bluish-white and translucent with basophilic staining.

A

Hyaline cartilage

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16
Q

Which type of cartilage is known as a shock absorber?

A

Hyaline cartilage

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17
Q

In the perichondrium chondrogenic cells can develop into what?

A

Chondroblasts

18
Q

Chondroblasts will build and build until they surround themselves and get stuck in a ______. Once in the _______ they are termed chondrocytes?

A

Lacuna

19
Q

Clustered chondrocytes that are found in their lacuna are called what?

A

Isogenic clusters

20
Q

Which layer of hyaline cartilage is found to be acidophilic or eosinophilic?

A

Perichondrium

21
Q

Which layer of hyaline cartilage contains chondrogenic cells that produce chondroblasts?

A

Perichondrium

22
Q

Which layer of hyaline cartilage houses chondroblasts which synthesize and secrete ECM?

A

Growing cartilage

23
Q

Once chondroblasts get stuck in a lacuna and are completely surrounded by ECM they change their name to what?

A

Chondrocytes

24
Q

Which layer houses chondrocytes that secrete additional matrix via interstitial growth?

A

Existing cartilage

25
Q

There are two types of matrix what are they?

A
  1. Territorial matrix

2. Interterritorial matrix

26
Q

Which type of matrix surrounds each chondrocyte and isogenous group and is rich in GAGs?

A

Territorial matrix

27
Q

Which type of matrix is further away from each chondrocyte and isogenous group which is collagen abundant?

A

interterritorial matrix

28
Q

Chondrocytes undergo what kind of growth giving rise to isogenous groups?

A

mitosis

29
Q

_____ cartilage is made up largely of water plus elastic fibers; is found composing parts of the ear and epiglottis; has a perichondrium present; and appears yellowish in color with elastic fibers prominent throughout.

A

Elastic cartilage

30
Q

Which type of cartilage has a higher ratio of chondrocytes to matrix? Hyaline or Elastic?

A

Elastic cartilage

31
Q

Which type of cartilage has fewer isogenous groups? Hyaline or Elastic?

A

Elastic

32
Q

In a staining image of elastic cartilage what will you find running between each associated chondrocyte that is in it’s lacunae?

A

Elastic networks

33
Q

As we age our elastic cartilage shrinks and is partially replaced by what?

A

White adipose tissue

34
Q

_____ cartilage has an ECM made of mostly type I & II collagen fibers and less proteoglycans than other cartilages?

A

Fibrocartilage

35
Q

_____ cartilage is found in intervertebral discs, pubic symphysis, and major tendon-bone anchorages

A

Fibrocartilage

36
Q

Fibrocartilage is missing one major component which the other two have?

A

Perichondrium

37
Q

______ cartilage appears more acidophilic, has long rows of chondrocytes separated by collagen fibers.

A

Fibrocartilage

38
Q

Which type of cartilage would we find where there are a lot of pulling forces as well as compression forces?

A

Fibrocartilage

39
Q

Fibrocartilage is a good intermediate of _____ cartilage and _____ connective tissue

A

Hyaline cartilage and dense connective tissue

40
Q

How can you tell the difference between dense regular CT and Fibrocartilage on a staining?

A
  1. Fibrocartilage has chondrocytes in their lacunae

2. Type I collagen in stress lines

41
Q

Cartilage is considered a connective tissue because it is derived from ______ and is composed of cells within an ________ _______.

A

Mesenchyme,

Extracellular matrix

42
Q

The differences in the _____ ______ make the 3 types of cartilage stand out from one another.

A

Extracellular matrix