L2 biochem Flashcards
list 2 folic acid antagonist
methotrexate
sulfonamide
(both competitive inhibitor for folic acid bcs has same structure)
list function of folic acid/tetrahydrofolate/FH4
-one carbon metabolism
-synthesis of DNA
-synthesis of RBCs
-treatment of heart disease
-prevent neural tube defect in infant
what is active form of folic acid
tetrahydrofolate
enumerate symptoms of folic acid deficiency
-megaloblastic anemia
-thrombocytopenia
-leucopenia
-neural tube defect
-impaired growth
enumerate causes of folic acid deficiency
-increase demand like pregnancy
-impaired absorption (pathological changes in small intestine)
-use of drug like methotrexate
-diet
-chronic alcoholic
what is indicator to detect folate deficiency
formiminoglutamic acid FIGLU
what is source of folic acid
plant
animal
what is source of vitamin B12
animal source only like liver milk egg fresh shrimp
vitamin B12 is
-cobalamine/anti pernicious anemia
list 4 functions of vitamin B12
-isomerization of methylmalonyl CoA
-essential of myelination of myelin sheath and nerve
-DNA synthesis
-remethylation of homocysteine to methionine
causes of B12 deficinecy?
-vegeterian diet
-heavy drinking
-surgery
-long term use of acide-reducing drug
-atrophic gastritis
manifestation of vitamin B12 defeciency
-pernicious anemia
-glossitis
-stomatitis
-neuropsychiatric manifestation( improper myelination of myelin sheath)
why vitamin B12 deficiency is rare
because it is stored in the liver for several year
what is marker used to detect B12 deficiency?
methylmalonyl CoA
recommended daily allowance
1-2 ug daily
