L17:anti anxiety drugs Flashcards
all benzodiazepines end in the suffix :
-epam
non bendoziazepine anti anxiety drugs are also known as the _____ drugs
z drugs
what are the other 2 classes of anti anxiety drugs other than BZP and non BZP
barbiturates and miscellaneous
what are the other 2 classes of anti anxiety drugs other than BZP and non BZP
barbiturates and miscellaneous
what is the mechanism of benzodiazepines ?
they act on GABAa receptors and produces CNS depression and increase frequency of GABA gated CL channels opening
what are benzodiazepines used for ?
-hypnotic
-anxiolytic
-pre-anesthesia/ induce anesthesia
-anti-convulsant
-to treat alcohol withdrawal symptoms
what are the adverse effects of benzodiazepines?
dose dependent drowsiness
impairment of motor skills
(gen 1 antihistamines also have the same problems )
which drug is used to reverse BZP anesthesia or overdose toxicity ?+reverses action of non BZP drugs
flumazenil
what quality of BZP drugs is absent from non-BZP drugs?
non BZP drugs have no anti-convulsant prosperities
what’s the mechanism of non-BZP drugs and how is their action different from BZP drugs ?
they bind selectively to BZP receptors to exert hypnotic effect and produce sleep that is more natural than that produced by BZP drugs
non-BZP drugs produce physical dependency ?
no
what is the mechanism of barbiturates ?
act on GABAa receptors , potentiating GABA mediated inhibitory effect
give an example of : ultra short acting , short acting , and long acting barbiturates
ultra-short acting : thiopental
short acting: pentobarbital
long acting : phenobarbital
what are the adverse effect of barbiturates ?
enzyme induction resulting from repeated use
abuse liable
impairment of judgment
respiratory depression
which drug surpasses sympathetic overactivity , GIT upset , palpitations , tremors , and hypertension in anxiety?
propranolol
