L17 Adrenoceptor antagonist - alpha blockers Flashcards

1
Q

Phenoxybenzamine is which alpha receptors blocker?

A
  • a1 & a2
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2
Q

Effects of phenoxybenzamine on alpha receptors

A
  • a1: orthostatic hypotension
  • a2: tarcycardia
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3
Q

Therapeutic uses of phenoxybenzamine

A
  • Pheochromocytoma
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4
Q

Side effects of phenoxybenzamine

A

nasal stuffiness
orthostatic hypotension
tarchycardia
inhibition of ejaculation
fatigue
nausea

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5
Q

Phentolamine is which alpha receptors blocker?

A

a1 , a2

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6
Q

Therapeutic use of phentolamine

A

Pheochromocytoma

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7
Q

Side effects of phentolamine

A

Orthostatic hypotension
Tachycardia
Arrhythmias
Myocardial ischemia

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8
Q

Prazosin is which alpha antagonist

A

a1

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9
Q

Therapeutic use of prazosin

A

Antihypertensive
treat BPH (urinary retention)

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10
Q

Side effect of prazosin

A

1st dose phenomenon - sudden and severe drop in BP when change from lying to standing position
- Hypotension
- Nasal congestion
- Headache
- Drowsiness
- Tiredness
- Palpitation

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11
Q

Yohimbine is which alpha antagonist

A
  • a2
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12
Q

Uses of yohimbine (4)

A
  • treat orthostatic hypotension
  • increase BP
  • veterinary medicine to reverse anaesthesia produce by xylazine
  • treat erectile dysfunction
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13
Q

Which alpha antagonists cause pheochromocytoma

A
  • Phenoxybenzamine
  • Phentolamine
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14
Q

Treat hypertensive emergencies

A
  • labetalol (a1 antagonist) is useful in high BP due to excess circulating conc. of alpha agonists
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15
Q

Chronic hypertension

A
  • prazosin
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16
Q

Urinary obstruction

A
  • prazosin, doxazosin, terazosin, tamsulosin
17
Q

peripheral vascular disease - occasional raynaud’s phenomenon

A

prazosin/ phenoxybenzamine
(ca2+ channel blocker more preferable due to side effect of prazosin and phenoxybenzamine)