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Pharmacology 1 > L13 Antimuscarinic Drug > Flashcards

L13 Antimuscarinic Drug Flashcards

1
Q

Parkinson’s disease

A
  • benzhexol, benztropine
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2
Q

Motion sickness

A
  • hyoscine
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3
Q

Ophthalmoscopic examination of retina (mydriasis, cycloplegia)

A
  • atropine (5-6 days)
  • homatropine (12-24h)
  • cyclopentolate (3-6h)
  • tropicamide (15-60m)
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4
Q

Preoperative medication for anesthesia- to dry airway secretion

A

IV atropine, glycopyrrolate

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5
Q

Asthma, COPD

A
  • Ipratropium
  • Tiotropium
    (bronchodilators)
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6
Q

Marked reflex vagal discharge (vasovagal attack, hyperactive carotid sinus reflexes)

A

IV atropine

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7
Q

Peptic ulcer disease

A
  • Propantheline, pirenzepine, glycopyrrolate
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8
Q

Disease involves autoantibodies that exert parasympathomimetic actions on the heart- Chagas’ disease

A

Atropine

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9
Q

Antispasmodic and decrease hypermotility in diarrhoea

A

Hyoscine

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10
Q

Irritable bowel syndrome

A

Dicyclomine

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11
Q

Relieve bladder spasm

A

Oxybutynin

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12
Q

Urinary incontinence

A

Oxybutynin, tolterodine, fesoterodine, darifenacin, solifenacin, propiverine

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13
Q

Atropine toxicity in adult

A
  • Dry mouth
  • Mydriasis
  • Tachycardia
  • Hot& flushed skin
  • Agitation (焦虑）
  • Delirium （神智失常）
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14
Q

Treatments

A

Cool blanket > hyperthermia
Seizure > diazepam
Antidote > physostigmine

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15
Q

Pharmacodynamic - CNS effect

A
  1. low dose: sedation, mild restlessness
  2. high dose: agitation, excitement, disorientation
  3. reduction of motion sickness
  4. anti-parkinsonism
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16
Q

Pharmacodynamic - Genitourinary tract

A
  • Urinary retention (relaxation of smooth muscle of ureters and bladder wall)
17
Q

Pharmacodynamic - Eyes

A
  1. mydriasis
  2. cycloplegia
  3. dry eyes
  4. increase IOP
18
Q

selective M1 antagonists

A

Pirenzepine, telenzepine

19
Q

non-selective M antagonist

A

Atropine, hyoscine

20
Q
A

Pharmacology 1 (6 decks)

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