L15: beta-blockers & treatment of cardiovascular disease Flashcards
1
Q
What are beta blockers?
A
Drugs that block beta adrenergic receptors to reduce workload on the heart
2
Q
2 types of adrenergic receptors
A
1) a-adrenergic receptor
2) b-adrenergic receptors
3
Q
What kind of receptors are adrenergic receptors?
A
GPCR
4
Q
Where is adrenaline released from?
A
Adrenal glands
5
Q
What is noradrenaline released by?
A
Sympathetic neurons
6
Q
How do b-adrenoceptors increase cAMP to mediate signallling?
A
Couple to G proteins
7
Q
Why is it better to use bisoprolol instead of propranolol to treat high heart rate?
A
Propranolol is non-selective
8
Q
What is angina?
A
Reduced blood flow to the heart
9
Q
What is atherosclerosis?
A
Arteries become narrowed, difficult for blood to flow through them
10
Q
A
