L12: Connective Tissue II (alyaa) Flashcards
The three main types of CT fibers are:
- Collagen
- Reticular
- Elastic
Name each protein that make up the 3 main types of CT fibers?
- Collagen: protein collagen
- Reticular: protein collagen type III
- Elastic: elastin protein
True or false?
The three main types of CT fibers are composed of short, thick, protein monomers which are present in variable proportions in different CTs
FALSE
The three main types of CT fibers are composed of LONG, SLENDER, protein POLYMERS which are present in variable proportions in different CTs
What type of fibers do we find in the tendon?
Collagen fibers
What type of fibers will we find in the adrenal cortex?
Reticular fibers
What type of fiber will we find in the aortic wall?
Elastic lamellae
When it comes to the fibers in the aortic wall, we cannot say “elastic fibers” what do we call it instead?
Elastic lamellae
Main fiber type found in most supporting tissues?
Collagen fiber
Most abundant protein in the body?
Collagen fibers
True or false?
The most abundant protein in the body is elastin protein
False, it’s collagen fibers
Notable function of collagen fibers?
Provision of tensile strength
Color of fresh collagen fibers?
Fresh fibers are colorless, but when present in large
numbers, they cause the tissues in which they lie to
be white
Most abundant and widely distributed TYPE of collagen?
Type I Collagen
bones, dentin, tendons, dermis are all examples or where you would find…?
Collagen type 1
Describe the chain of Collagen type 1
2 of alpha chains are identical and 1 is different
Collagen type 2 is present mainly in?
Hyaline and elastic cartilages
True or false
Collagen type II are only in very thin fibril forms
True
Describe the chain in collagen type II
All 3 alpha chains are identical
(but different from those of other collagens)
Compare the difference between the alpha chains in collagen type I and type II?
TYPE I: 2 identical alpha chains and one is different
TYPE II: All 3 alpha chains are identical (but different from those of other collagens)
Which collagen type is usually associated with Collagen type I?
Collagen type III
What is a major collagenous component of Reticular
fibers ?
Collagen type 3
Which collagen type can co-polymerize with other types of collagen?
Collagen type 3
Which of these collagens does not form fibrils or fibers?
1) Type I Collagen
2) Type IV Collagen
3) Type III Collagen
Type IV Collagen
What does collagen type 4 make up?
basal lamina of epithelial & endothelial cells
What does collagen type 4 NOT form?
fibrils or fibers
The form of type 1 collagen
fibril, large banded fiber
fibril, large banded fiber is the form of
Collagen type 1
The form of type II collagen
fibril, small banded fiber
fibril, small banded fiber is the form of?
Type II & III collagens
Form of type III collagen?
fibril, small banded fiber
Form of type IV collagen?
network, sheetlike
Which collagens have a network form?
Type IV & VII Collagens
Which collagen forms a sheetlike form?
Type IV collagen
Type IV collagen is in thee form of?
network, sheetlike
Which collagen is 90% of body collagen?
Collagen type I
Which collagen makes up these tissues?
bone, skin, tendons, ligaments, cornea, internal organs
Type I collagen
Which collagen makes up these tissues?
cartilage (hyaline and elastic)
Type II collagen
Which collagen makes up these tissues?
internal organs (e.g., reticular fibers in lymph nodes, spleen, liver, blood vessels, skin)
Type III collagen
Which collagen makes up the basal lamina (lamina densa)?
Type IV collagen
What tissue does type VII collagen make up?
The tissue beneath the epithelia
The synthesizing cells that make up type 1 Collagen
fibroblast, osteoblast
The synthesizing cells that make up type II Collagen
Chondroblasts
The synthesizing cells that make up type III Collagen
fibroblast, reticular cell, smooth muscle cell, hepatocyte
The synthesizing cells that make up type IV Collagen?
Epithelial cell, muscle cell, schwann cells
The synthesizing cells that make up type VII Collagen
Epidermal cells
Type IV collagen forms a meshwork of what? AND what is that thing for?
A meshwork el procollagen for support 3 filtration of the basal lamina
List the functions of Type IV and VII collagens in the basement membrane
Type IV collagen forms a meshwork of procollagen for support and
filtration in the basal lamina.
Type VII collagen anchors the basal lamina to the underlying type I and III collagens of lamina reticularis of the basement membrane
Anchoring fibrils are made of…
Anchoring plaques are made of…
Anchoring fibrils: Type VII collagen
Anchoring plaques: Type IV collagen
Collagen synthesis:
1) Collagen is produced by?
2) The principle AA that make up collagen are?
3) The protein unit is? Its definition?
1) Collagen is produced by:
fibroblast, chondroblasts, osteoblasts and odontoblasts.
2) The principle AA’s that make up collagen are:
Glycine 33%
Proline 12%
Hydroxyproline 10%.
3) The protein unit is:
tropocollagen, which is an elongated molecule polymerized to form collagen fibrils.
Tropocollagen Molecules:
1) composition?
2) held together by?
3) Each complete turn of the helix spans distance of?
4) The length and width of each is?
1) Each molecule is composed of 3 subunit polypeptide α chains (can be same or different) intertwined in a right-handed triple helix.
2) Held together by hydrogen bonds.
3) Each complete turn of the helix spans distance of 8.6 nm.
4) Length: 280 nm
Width: 1.5 nm.
1) α chains of tropocollagen consist of what amino acids?
2) And every 3rd AA must be ….. to fit in triple helix?
1) Collagen fibers consist of bundles of threadlike fibrils bound together by?
2) fibrils are composed of arrays of?
Collagen Fibers by EM Characteristic feature:
