L11- synaptic transmission Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

how can APs be transmitted (between cells)

A

synapses

gap junctions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

explain the mechanism of synaptic transmissiom

A
  1. depolarisation arrives at pre SM and causes opening of voltage gated Ca2+ channels
  2. Ca2+ influx causes NT vesicles to fuse with pre S membrane
  3. NT released into cleft and diffuses to post SM
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are some structural features of a synapse

A

mitochondria
vesicles
channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is an end plate potential

A

a sub threshold potential - no AP generated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what happens to propagation of an end plate potential

A

decreases away from the site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is a MEPP and how can it lead to an AP

A

minature end plate potential

  1. summation of MEPPs leads to end plate potential (EPSP)
  2. several end plate potentials may reach threshold
  3. threshold = AP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

explain knee jerk reflex

A
  1. hit to tendon in knee causes stretch, which sends signal to CNS
  2. sends EPSPs to extensor muscle
  3. sends IPSPs to antagonist muscle (flexor)
  4. knee jerks
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

define EPSP

define IPSP

A

excitatory post synaptic potential

inhibitory post synaptic potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what do EPSPs do

A

add to generate depolarisation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what do IPSPs do

A

add to generate repolarisation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what do EPSPs and IPSPs do to eachother

A

cancel eachother out

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

define temporal summation

A

several small potentials (EPSPs) arrive successively from one neuron and combine to produce (possible) AP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

define spacial summation

A

several EPSPs arrive from several different neurons (eg dendrites) to combine and produce (possible) AP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what can cause inhibition of a neuron

A

opening cl- channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly